The integrated response of a population of neurones during conditioning results in long-term (days) changes of specific membrane currents within identified neurones. Prolonged elevation of intracellular calcium during conditioning causes a persistent increase of excitability by reducing K+ currents (IA and probably ICa2+-K+) in the membranes of identified somata. This Ca2+-mediated reduction of K+ currents, which encodes a learned stimulus association is thought to involve changes of Ca2+-calmodulin-dependent phosphorylation of distinct membrane proteins. These changes are contrasted with the short-term regulation of currents by neurohormones during altered behavioural states such as arousal.
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JOURNAL ARTICLE| 01 September 1984
Changes of membrane currents during learning
D. L. Alkon
Online Issn: 1477-9145
Print Issn: 0022-0949
© 1984 by Company of Biologists
J Exp Biol (1984) 112 (1): 95–112.
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D. L. Alkon; Changes of membrane currents during learning. J Exp Biol 1 September 1984; 112 (1): 95–112. doi: https://doi.org/10.1242/jeb.112.1.95
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