Measurements of metabolite concentrations before and immediately after swimming of trout to exhaustion indicate that all three potential endogenous fuels of anaerobic metabolism [glycogen, phosphocreatine (PCr) and adenosine triphosphate (ATP)] are utilized during anaerobic white muscle work. Lactate, H+, creatine Pi, NH4+ and inosine monophosphate (IMP) are formed in the process. Glycolysis is considered to be functionally (if loosely) coupled to adenylate depletion by setting up conditions favouring AMP-deaminase-catalysed formation of IMP and NH3. During recovery under these experimental conditions, glycolysis appears to outcompete oxidative metabolism as an ADP acceptor; therefore, in this kind of white muscle, glycolysis is also linked to IMP reconversion to AMP and thus to adenylate replenishment. The net process generates H+, which is why ATP replenishment must be completed before PCr concentrations can be returned to pre-exercise values.
JOURNAL ARTICLE| 01 May 1987
Role of glycolysis in adenylate depletion and repletion during work and recovery in teleost white muscle
G. P. Dobson
P. W. Hochachka
Online Issn: 1477-9145
Print Issn: 0022-0949
© 1987 by Company of Biologists
J Exp Biol (1987) 129 (1): 125–140.
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G. P. Dobson, P. W. Hochachka; Role of glycolysis in adenylate depletion and repletion during work and recovery in teleost white muscle. J Exp Biol 1 May 1987; 129 (1): 125–140. doi: https://doi.org/10.1242/jeb.129.1.125
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