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Journal Articles
J Cell Sci (2018) 131 (12): jcs217398.
Published: 21 June 2018
...Matthew N. J. Seaman; Aamir S. Mukadam; Sophia Y. Breusegem ABSTRACT The retromer complex is a vital component of the endosomal protein sorting machinery necessary for sorting into both the endosome-to-Golgi retrieval pathway and also the endosome-to-cell-surface recycling pathway. Retromer...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2269–2277.
Published: 1 July 2015
... Secretory pathway Sorting TM9 protein Transmembrane domain Localization of membrane receptors at the surface of eukaryotic cells is often essential for them to perform their specific functions, such as cellular adhesion (e.g. integrins), nutrients capture (e.g. transferrin receptor) or signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 397–407.
Published: 15 January 2015
... with CIN85, resulting in reduced EGFR ubiquitylation. Taken together, these data provide a mechanistic explanation of how SEPT9, though acting exclusively at the plasma membrane, impairs the sorting of EGFRs into the degradative pathway. References Amir   S. , Golan   M. , Mabjeesh   N. J...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (17): 3745–3756.
Published: 1 September 2014
... by The Company of Biologists Ltd 2014 PI4K2A VAMP3 PtdIns4 P Vesicle fusion Sorting SNARE The plasma membrane pool of VAMP3 was detected in non-permeabilized cells expressing a VAMP3 construct with an HA tag fused to the extracellular C-terminus, as previously described ( Gordon et al., 2009...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2793–2801.
Published: 1 July 2014
... mechanisms of sorting. In this Commentary, we discuss the recent advances in the field of GPI-AP sorting focusing on the mechanisms operating at the level of the exit from the ER and from the trans-Golgi network (TGN), which take place, respectively, in yeast and in polarized mammalian cells. By considering...
Journal Articles
J Cell Sci (2013) 126 (5): 1155–1163.
Published: 1 March 2013
... hormone hyposecretion, supporting essential PREPL functions in AP-1-dependent secretory pathways. * Author for correspondence ( pschu@gwdg.de ) 2 1 2013 © 2013. Published by The Company of Biologists Ltd 2013 Adaptin Clathrin Prolyl-oligopeptidase Sorting Trans-Golgi network...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (20): 4693–4702.
Published: 15 October 2012
...Matthew N. J. Seaman Summary The retromer complex is a vital element of the endosomal protein sorting machinery that is conserved across all eukaryotes. Retromer is most closely associated with the endosome-to-Golgi retrieval pathway and is necessary to maintain an active pool of hydrolase...
Journal Articles
J Cell Sci (2010) 123 (19): 3329–3335.
Published: 1 October 2010
...Valentina Mercanti; Anna Marchetti; Emmanuelle Lelong; Franck Perez; Lelio Orci; Pierre Cosson Efficient sorting of proteins is essential to allow transport between intracellular compartments while maintaining their specific composition. During endocytosis, membrane proteins can be concentrated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (24): 4001–4007.
Published: 15 December 2008
...Simona Paladino; Stephanie Lebreton; Simona Tivodar; Vincenza Campana; Rosaria Tempre; Chiara Zurzolo To understand the mechanism involved in the apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) we fused to the C-terminus of GFP the GPI-anchor-attachment signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 865–876.
Published: 15 March 2008
...Anna Dukhovny; Andreas Papadopulos; Koret Hirschberg The sorting and concentration of cargo proteins within ER exit sites (ERESs) is a fundamental function of the secretory machinery. The mechanism by which peripheral coat complexes and their small GTPase effectors mediate this function with export...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (1): 191–199.
Published: 1 January 2007
...Elisabetta Zuccato; Emma J. Blott; Oliver Holt; Sara Sigismund; Michael Shaw; Giovanna Bossi; Gillian M. Griffiths Fas ligand (FasL), a potent mediator of apoptosis expressed by CTL and NK cells, is sorted into the inner vesicles of secretory lysosomes for release via exosome-like vesicles...
Journal Articles
J Cell Sci (2006) 119 (10): 2003–2014.
Published: 15 May 2006
... generated missense and deletion mutants of full-length OA1. Using this approach, we identified two separate sorting signals that are both necessary and sufficient for intracellular retention, as well as lysosomal and melanosomal localization, in melanocytic and non-melanocytic cells. These sorting signals...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (18): 4295–4310.
Published: 15 September 2005
.... paxB – strains are less adhesive to the substrate, they can aggregate but multicellular development from the mound stage onwards is severely impeded. paxB – strains are defective in proper cell type proportioning, cell sorting, slug migration and form-defective fruiting bodies. Mutation of a conserved...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (10): 2105–2118.
Published: 15 May 2005
... on the sorting and recycling of membrane proteins. In this study we show that the type I membrane protein Tb MBAP1, an L-(+)-tartrate-sensitive acid phosphatase, is present in all endosomal membranes but is virtually absent from the lysosome membrane (where this type of protein is mainly found in other organisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (7): 1363–1372.
Published: 1 April 2005
...-neuronal secretory cells. * Author for correspondence (e-mail: histol3@post.tau.ac.il ) 6 1 2005 © The Company of Biologists Limited 2005 2005 Sorting Glycosylation Synaptotagmin RBL-2H3 Synaptotagmins comprise a family of structurally related proteins that are highly...
Journal Articles
J Cell Sci (2002) 115 (24): 4827–4841.
Published: 15 December 2002
... release, the present study establishes that a CgA-GFP fusion protein expressed in neuroendocrine PC12 cells is trafficked to the dense core secretory granule and thereby sorted to the regulated pathway for exocytosis. We show that information necessary for such trafficking is contained within the N...
Journal Articles
J Cell Sci (2002) 115 (6): 1149–1160.
Published: 15 March 2002
... in the localisation of procollagen to transport complexes that now also contain ERGIC-53 and are inhibited in their transport to the Golgi complex. These data reveal the existence of an early COPI-dependent,pre-Golgi cargo sorting step in mammalian cells. (e-mail: david.stephens@bristol.ac.uk pepperko@embl...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (15): 2831–2841.
Published: 1 August 2001
... significant sequence homologies with several melanosomal proteins. We have studied its intracellular traffic in both pigmented and non-pigmented cells. We report that a di-leucine-based sorting signal (ExxPLL) present in the cytoplasmic domain of QNR-71 is necessary and sufficient for its proper targeting...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 85–92.
Published: 1 December 1993
.... In contrast, the hemagglutinin of FPV, after accumulation in the Golgi apparatus, moved to the axons. These results suggest that the mechanism of sorting of viral glycoproteins might be similar in neurons and MDCK cells, a cell line of epithelial origin. In these cells the VSV glycoprotein...
Journal Articles
In collection:
Metabolism
J Cell Sci (1993) 104 (3): 607–612.
Published: 1 March 1993
... in amino acid sequence. These are the domains that likely contain information that is recognized by cytosolic machinery to determine the eventual destination of the pro- tein in the cell. Two separate examples of glucose trans- porter targeting will be discussed. The first is that of sort- ing in polarized...