... Limited 2004 2004 v-Src Protein tyrosine kinase FAK Focal adhesions Integrins Transformation The protein tyrosine kinase v-Src is the transforming product of Rous sarcoma virus, the first identified oncogenic retrovirus. Src, the cellular counterpart of v-Src, is a member of a multigene...

... cellular phenotypes. The cell-surface receptors for a wide range of polypeptide hormones possess protein tyrosine kinase activity, which is induced by binding of the appropriate extracellular ligand. Tyrosine phosphorylation can act as a molecular switch, by initiating the recruitment of cytoplasmic...