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Keywords: phospholipase C
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Journal Articles
Journal Articles
J Cell Sci (2017) 130 (21): 3728–3739.
Published: 1 November 2017
... that stimulate phospholipase C (PLC) and, thereby, formation of inositol 1,4,5-trisphosphate (IP 3 ). IP 3 then binds to IP 3 receptors (IP 3 Rs) to stimulate Ca 2+ release from the endoplasmic reticulum (ER). Vertebrates express three subtypes of IP 3 R and numerous splice variants but each contributes...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (7): 1683–1692.
Published: 1 April 2012
.... * These authors contributed equally to this work ‡ Author for correspondence ( rfratti@illinois.edu ) 7 11 2011 © 2012. 2012 Fusion Phosphoinositide SNARE HOPS Phospholipase C Actin dynamics Membrane trafficking is utilized by all eukaryotes for the transportation of cargo...
Journal Articles
J Cell Sci (2011) 124 (19): 3292–3304.
Published: 1 October 2011
... © 2011. 2011 WDR36 Thromboxane A 2 GPCR G protein Phospholipase C G-protein-coupled receptors (GPCRs) are the largest family of membrane receptors responsible for mediating extracellular to intracellular signalling. They respond to a variety of stimuli, including light, hormones...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2582–2590.
Published: 1 August 2011
...Michail Nomikos; Khalil Elgmati; Maria Theodoridou; Brian L. Calver; George Nounesis; Karl Swann; F. Anthony Lai Phospholipase C-zeta (PLCζ) is a strong candidate for the mammalian sperm-derived factor that triggers the Ca 2+ oscillations required for egg activation at fertilization. PLCζ lacks...
Journal Articles
J Cell Sci (2008) 121 (11): 1803–1814.
Published: 1 June 2008
..., inhibition of myosin II induced the outgrowth of F-actin-rich surface protrusions. The development of these protrusions was abrogated after inhibition of F-actin polymerization or of phospholipase C (PLC) activity, as well as after overexpression of a dominant-negative ADF/cofilin. Surface protrusions were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1363–1372.
Published: 1 May 2008
... are complexed in the basal state. J. Biol. Chem. 281 , 23999 -24014. Dowal, L., Provitera, P. and Scarlata, S. ( 2006b ). Stable association between G alpha(q) and phospholipase C beta 1 in living cells. J. Biol. Chem. 281 , 23999 -24014. Evanko, D. S., Thiyagarajan, M. M., Takida, S...
Journal Articles
J Cell Sci (2006) 119 (10): 2084–2094.
Published: 15 May 2006
... technique, we report that plasma membrane PtdIns(4,5) P 2 becomes transiently depleted upon activation of exocytosis, and is not detected on the membranes of fusing granules. Depletion is caused by phospholipase C activity, and is mandatory for exocytosis. Although phospholipase C is required for Ca 2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (8): 1469–1475.
Published: 15 April 2006
... pathogenic roles for GIT proteins in Huntington's disease and HIV infection. * Author for correspondence (e-mail: bradford_berk@urmc.rochester.edu ) 6 2 2006 © The Company of Biologists Limited 2006 2006 GIT1 G-protein-coupled receptor Endosomes Phospholipase C Among...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (17): 3887–3896.
Published: 1 August 2004
... seems counterintuitive, as inhibition of phospholipase C would be expected to increase cellular levels of PtdIns(4,5) P 2 and hence increase actin polymerization. Our confocal images suggest, however, that F-actin might accumulate at the poles of U7-treated cells, consistent with the idea that PtdIns...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (12): 2513–2521.
Published: 15 May 2004
...-dependency is unknown, despite their importance for egg activation and embryo development. We recently identified a novel, sperm-specific phospholipase C (PLCzeta; PLCζ) that triggers Ca 2+ oscillations similar to those caused by sperm. We show that PLCζ-induced Ca 2+ oscillations also occur exclusively...
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2002) 115 (24): 5013–5025.
Published: 15 December 2002
... treatments do not affect growth, we suggest that the small conductance channel generates the obligatory tip-high Ca 2+ gradient during hyphal growth. Since IP 3 production must be catalyzed by tip-localized phospholipase C, we show that a number of phospholipase C inhibitors [neomycin,1-[6-((17β-3...
Journal Articles
J Cell Sci (2002) 115 (10): 2233–2239.
Published: 15 May 2002
...Ansuman Chattopadhyay; Graham Carpenter Phospholipase C-γ1, a tyrosine kinase substrate, hydrolyses phosphatidylinositol 4,5-bisphosphate to produce inositol 1,4,5-trisphosphate and diacylglycerol, which act as second messenger moleculesto mobilize intracellular calcium and activate protein kinase...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (20): 3759–3766.
Published: 15 October 2001
.... Consistent with previous observations, phospholipase C (PLC) inhibitors block anesthetic effects on the PIP 2 and cytoplasmic Ca 2+ levels, as well as the drop in adhesion. Therefore, we suggest that PLC activity is increased by amine anesthetics at the cytoplasmic surface of the plasma membrane, which...
Journal Articles
Journal Articles
J Cell Sci (1996) 109 (7): 1947–1955.
Published: 1 July 1996
...Ben Spungin; Haim Breitbart ABSTRACT We have previously shown that two intracellular events which occur during capacitation of bovine sperm are the formation of actin filaments on the plasma and outer acrosomal membranes and the attachment of a PIP 2 -specific phospholipase C (PLC) to this membrane...