...Alice Nemajerova; Ute M. Moll ABSTRACT p73 (TP73) belongs to the p53 family of transcription factors. Its gene locus encodes two opposing types of isoforms, the transcriptionally active TAp73 class and the dominant-negative DNp73 class, which both play critical roles in development and homeostasis...

...David Goldschneider; Karine Million; Anne Meiller; Hedi Haddada; Alain Puisieux; Jean Bénard; Evelyne May; Sétha Douc-Rasy The p53 gene and its homologue p73 are rarely mutated in neuroblastoma. In recent studies, we showed that overexpression of ΔNp73α, an isoform lacking the N-terminal...

.... Furthermore, p73α, but not the oncogenic ΔNp73α, binds directly to HDAC1. We performed chromatin immunoprecipitation with antibodies against p73, ΔNp73, NFYB, p300 and HDAC1 at different periods after serum stimulation in serum-starved NIH3T3 cells. A marked decrease of ΔNp73, NF-YB and p300 was detected 6...

...David Goldschneider; Etienne Blanc; Gilda Raguénez; Michel Barrois; Agnès Legrand; Gwenaëlle Le Roux; Hedi Haddada; Jean Bénard; Sétha Douc-Rasy p73 , the first p53 gene homologue, encodes an array of p73 proteins including p73α full-length (TAp73α) and amino-truncated isoforms (ΔNp73α), two...

...M. Levrero; V. De Laurenzi; A. Costanzo; S. Sabatini; J. Gong; J. Y. J. Wang; G. Melino ABSTRACT The p53 gene is the most frequently mutated gene in human cancer. The identification of two homologues, p63 and p73, revealed that p53 is a member of a family of related transcription factors. Given...