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Keywords: p190RhoGAP
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Journal Articles
Journal Articles
J Cell Sci (2015) 128 (1): 50–60.
Published: 1 January 2015
...) p190RhoGAP-A (also known as ARHGAP35) has a role in cytokinesis and is involved in regulating levels of RhoA-GTP and contractility. Cells depleted of p190RhoGAP-A accumulate high levels of RhoA-GTP and markers of high RhoA activity in the furrow, resulting in failure of the cytokinetic furrow to progress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3356–3369.
Published: 1 August 2013
... during cell migration. Here we show that the spatial coordinators p190RhoGEF and p190RhoGAP regulate actin polymerization during leading edge protrusions by regulating the actin barbed end distribution and amplitude. The distribution of RhoC activity and proper balance of cofilin activation achieved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1852–1862.
Published: 1 June 2009
... and p190RhoGAP (p190A), leading to p190A tyrosine phosphorylation. Fibronectin-integrin-mediated FAK activation and phosphorylation promote SH2-mediated binding of p120RasGAP to FAK and FAK-mediated p190A tyrosine phosphorylation. The association of p120RasGAP with FAK facilitates the formation of a FAK...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (2): 223–231.
Published: 15 January 2004
... advantage of the prominent actin cytoskeleton in A7r5 cells we show here, that the molecular basis for the local inhibition of contractility is the specific recruitment of p190RhoGAP to specialised microdomains at the focal adhesion/stress fibre interface, which are constitutively enriched in cortactin...
Includes: Multimedia, Supplementary data
Journal Articles