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Keywords: focal adhesion kinase
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Journal Articles
J Cell Sci (2022) 135 (20): jcs259089.
Published: 14 October 2022
...Johanne Le Coq; Iván Acebrón; Bárbara Rodrigo Martin; Pilar López Navajas; Daniel Lietha ABSTRACT Focal adhesion kinase (FAK; also known as PTK2) was discovered three decades ago and is now recognised as a key player in the regulation of cell–matrix adhesion and mesenchymal cell migration. Although...
Journal Articles
In collection:
Adhesion
J Cell Sci (2022) 135 (2): jcs258471.
Published: 28 January 2022
... how integrin α6β4 cooperates with other integrins to drive migration and invasive growth. Integrin α6β4 Triple negative breast cancer Focal adhesions Fibrillar adhesions Focal adhesion kinase Vimentin National Institutes of Health http://dx.doi.org/10.13039/100000002 R01...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion , Cytoskeleton
J Cell Sci (2021) 134 (13): jcs258321.
Published: 8 July 2021
... Competing interests The authors declare no competing or financial interests. 15 12 2020 1 6 2021 © 2021. Published by The Company of Biologists Ltd 2021 Highlighted Article: Fascin and focal adhesion kinase work in conjunction to regulate cell morphology during shape...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (8): 1580–1591.
Published: 15 April 2016
... and monocyte adhesion. Like for other atherogenic factors, oxLDL-induced proinflammatory responses requires integrin-dependent focal adhesion kinase (FAK, also known as PTK2) signaling; however, the mechanism by which FAK mediates oxLDL-dependent NF-κB signaling has yet to be revealed. We now show that oxLDL...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4601–4614.
Published: 15 December 2015
... contributes to fascin-dependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin–microtubule association in the control of adhesion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1394–1405.
Published: 1 April 2014
.... Furthermore, we found that CasSD phosphorylation in the early stages of cell spreading required: (1) integrin anchorage and integrin-mediated activation of SFKs, (2) association of Cas with focal adhesion kinase (FAK), and (3) N-WASP-driven actin-assembly activity. These findings, and analyses...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 5960–5973.
Published: 15 December 2012
... Lee Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic and pathological migration of adherent cells. However, it is unclear how TM4SF5 signaling mediates the activation of cellular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (2): 171–180.
Published: 15 January 2010
... by normal MDCK cells, myosin-II and focal adhesion kinase (FAK) are activated in Src cells, which further activate downstream mitogen-activated protein kinase (MAPK). Importantly, activation of these signalling pathways depends on the presence of surrounding normal cells and plays a crucial role in apical...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (3): 357–367.
Published: 1 February 2009
... differentiate or undergo apoptosis depending on their local adhesive interactions. Apoptosis in response to an inappropriate ECM environment is termed `anoikis', or homelessness. Several studies, utilising a variety of cell types, have indicated a common, crucial role for focal adhesion kinase (FAK...
Journal Articles
J Cell Sci (2006) 119 (1): 47–55.
Published: 1 January 2006
... activity is required for netrin to stimulate UNC5 tyrosine phosphorylation in neurons and transfected cells. The SH2 domain of Src kinase directly interacts with the cytosolic domain of UNC5 in a tyrosine-phosphorylation-dependent manner. Furthermore, the tyrosine kinase focal adhesion kinase (FAK) is also...
Journal Articles
J Cell Sci (2005) 118 (19): 4415–4425.
Published: 1 October 2005
...Abdelkader Hamadi; Maya Bouali; Monique Dontenwill; Herrade Stoeckel; Kenneth Takeda; Philippe Rondé One of the major tyrosine phosphorylation activities linked to integrin signalling is that of focal adhesion kinase (FAK). High amounts of FAK are located at specialised subcellular compartments...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (10): 2189–2200.
Published: 15 May 2005
... Limited 2005 2005 Actin cytoskeleton Fibronectin Staphylococci Focal complexes Focal adhesion kinase Cortactin Integrins are heterodimeric surface receptors of multicellular organisms critically involved in cell-cell and cell-matrix adhesion. In addition to their structural role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (14): 2845–2855.
Published: 15 July 2003
... and cytoskeletal proteins, the SETA-interacting protein AIP1, which is a rat ortholog of the Xenopus src substrate Xp95, strongly interacted with structural proteins of the cytoskeleton, including actin and tubulins. Both SETA and AIP1 interacted with focal adhesion kinase (FAK) and proline rich tyrosine kinase 2...
Journal Articles
J Cell Sci (2003) 116 (6): 975–986.
Published: 15 March 2003
... adhesion development by inducing cellular contraction. We show here that, 2 minutes after addition of the microtubule-disrupting drug nocodazole,the local densities of the focal adhesion-associated proteins vinculin,paxillin and focal adhesion kinase (FAK) are significantly elevated and the focal adhesion...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (14): 2665–2672.
Published: 15 July 2001
.... and Buck, C. ( 1990 ). Integrin distribution in malignant melanoma: association of the β 3 subunit with tumor progression. Cancer Res. 50 , 6757 -6764. Calalb, M. B., Zhang, X., Polte, T. R. and Hanks, S. K. ( 1996 ). Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src...
Journal Articles
J Cell Sci (1994) 1994 (Supplement_18): 109–113.
Published: 1 January 1994
... of the cell. This brief review considers recent information on the role of focal adhesion-associated protein tyrosine kinases in integrin-regulated cell signalling. * Author for correspondence © The Company of Biologists Limited 1994 1994 integrin paxillin focal adhesion kinase Journal...