... system is held in place by a structure called the Z-disc, which anchors the actin filaments. Myosin filaments, in turn, are anchored to another structure called the M-line. Most of the complex architecture of myofibrils can be reduced to studying the Z-disc, and recently, important advances regarding...

... protein. In this study, we newly identify NRIP as a Z-disc protein in skeletal muscle. NRIP-knockout mice were generated and found to have reduced muscle strength, susceptibility to fatigue and impaired adaptive exercise performance. The mechanisms of NRIP-regulated muscle contraction depend on NRIP being...

... microscopy and quantitative analysis, we demonstrate that expression of the mutant desmin K190A in primary myocytes results in a significant reduction in assembled endogenous nebulin and desmin at the Z-disc. Non-uniform actin filaments were markedly prevalent in myocytes expressing GFP-tagged desmin K190A...

...Benjamin Meder; Steffen Just; Britta Vogel; Jessica Rudloff; Linda Gärtner; Tillman Dahme; Inken Huttner; Alexandra Zankl; Hugo A. Katus; Wolfgang Rottbauer In muscle cells, a complex network of Z-disc proteins allows proper reception, transduction and transmission of mechanical and biochemical...

...Abdelaziz Beqqali; Jantine Monshouwer-Kloots; Rui Monteiro; Maaike Welling; Jeroen Bakkers; Elisabeth Ehler; Arie Verkleij; Christine Mummery; Robert Passier In recent years, the perception of Z-disc function has changed from a passive anchor for myofilaments that allows transmission of force...

... and stabilization of the Z-discs in skeletal muscle. The essential role of myotilin in skeletal muscle is attested by the observation that certain forms of myofibrillar myopathy and limb girdle muscular dystrophy are caused by mutations in the human myotilin gene. Here we show by transfection, biochemical...