... that are critical for relaying the signal from upstream Wnt ligand–frizzled receptor binding to downstream effector β-catenin activation. However, the precise molecular nature and contribution of Dvl2 protein assemblies during Wnt signalling is unknown. Here, we show that Dvl2 forms protein condensates driven...

... show that Wnt signalling and FOXQ1 converge on a transcriptional programme linked to EMT and cell migration. Additionally, we demonstrate that FOXQ1 occupies Wnt-responsive elements in β-catenin target gene promoters and recruits a similar set of co-factors to the β-catenin-associated transcription...

...Lucie M. Wolf; Annika M. Lambert; Julie Haenlin; Michael Boutros ABSTRACT WNT signalling is important for development in all metazoans and is associated with various human diseases. The ubiquitin–proteasome system (UPS) and regulatory endoplasmic reticulum-associated degradation (ERAD) have been...

... dendrite arborisation by activating a non-canonical Wnt signalling pathway. Here, we identify the seven-transmembrane frizzled-7 (Fz7, also known as FZD7) as the receptor for Wnt7b-mediated dendrite growth and complexity. Importantly, Fz7 is developmentally regulated in the intact hippocampus...

...Meng-Ning Zhou; Ezgi Kunttas-Tatli; Sandra Zimmerman; Fangyuan Zhouzheng; Brooke M. McCartney The tumor suppressor Adenomatous polyposis coli (APC) has roles in both Wnt signaling and in actin and microtubule organization. Within the cell, APC proteins have been reported to localize...

..., Wnt7a, Wnt9a and Wnt11. Moreover, Wif-1 was able to block Wnt3a-mediated activation of the canonical Wnt signalling pathway. Consequently, Wif-1 impaired growth of mesenchymal precursor cells and neutralised Wnt3a-mediated inhibition of chondrogenesis in micromass cultures of embryonic chick limb-bud...

.... In this study, we show that in response to injury, myofibres activate Wnt ligand transcription and activate a reporter cell line that is sensitive to the canonical Wnt-signalling pathway. Activated satellite cells on isolated cultured myofibres show robust expression of activated-β-catenin (Act-β-Cat), a key...

...Thomas Schwarz-Romond; Ciara Metcalfe; Mariann Bienz Dishevelled (Dvl) proteins are cytoplasmic components of the Wnt signalling pathway, which controls numerous cell fate decisions during animal development. During Wnt signalling, Dvl binds to the intracellular domain of the frizzled transmembrane...

... ). A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. USA 99 , 7877 -7882. Ciani, L., Krylova, O., Smalley, M. J., Dale, T. C. and Salinas, P. C. ( 2004 ). A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J. Cell...

...Thomas Schwarz-Romond; Christien Merrifield; Benjamin J. Nichols; Mariann Bienz Dishevelled is a crucial effector upstream in the Wnt signalling pathway, but the molecular mechanism by which it transduces the Wnt signal remains elusive. Dishevelled is a cytoplasmic protein with a strong tendency...

... with the hypothesis that SFRP1 could participate in neural retina differentiation. * Author for correspondence (e-mail: bovolenta@cajal.csic.es ) 7 3 2003 © The Company of Biologists Limited 2003 2003 Chick Eye development Retina ganglion cells Wnt signalling GSK3β WNT...

... to phosphatase activation during adipogenesis in 3T3-L1 cells. J. Biol. Chem. 273 , 14063 -14066. Brantjes, H., Barker, N., van Es, J. and Clevers, H. ( 2002 ). TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. Biol. Chem. 383 , 255 -261. Breton, J. J. and Chabot...