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Keywords: Wnt
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Journal Articles
In collection:
Cilia and flagella
J Cell Sci (2023) 136 (16): jcs260807.
Published: 29 August 2023
..., a vital host defense mechanism. Multiciliated cell specification requires canonical Wnt signaling, which then must be turned off. Next, ciliogenesis and polarized ciliary orientation are regulated by noncanonical Wnt/planar cell polarity (Wnt/PCP) signaling. The mechanistic relationship between the Wnt...
Includes: Supplementary data
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Lipid biology
J Cell Sci (2022) 135 (5): jcs259145.
Published: 3 February 2022
... PtdIns P 2 Ror2 Wnt Kinase Phosphoinositide National Institutes of Health http://dx.doi.org/10.13039/100000002 R37-NS08174 R35-GM142690 National Science Foundation http://dx.doi.org/10.13039/100000001 IOS-1755004 This paper investigates in living cells...
Journal Articles
J Cell Sci (2021) 134 (1): jcs251645.
Published: 11 January 2021
... by osteoblasts to meet these synthetic demands are not well understood. WNT signaling is known to rapidly stimulate glutamine uptake during osteoblast differentiation. Using a cell biology approach, we identified two amino acid transporters, γ(+)-LAT1 and ASCT2 (encoded by Slc7 a7 and Slc1a5 , respectively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs209742.
Published: 28 September 2020
... diffused freely in the extracellular space. This view has since changed following the discovery that morphogens of the Wnt and Hedgehog (Hh) families are modified by various lipid adducts during their biosynthesis, providing them with high affinity for the membrane bilayer. Recent work performed in model...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (10): jcs210575.
Published: 22 May 2018
... has been shown to participate in signaling pathways, including Wnt signaling. XIAP regulates Wnt signaling by promoting the monoubiquitylation of the co-repressor Groucho/TLE family proteins, decreasing its affinity for the TCF/Lef family of transcription factors and allowing assembly...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2017) 130 (10): 1717–1729.
Published: 15 May 2017
... insight into the WNT-mediated regulation of the DNA damage response and suggest a novel role for the α-catenin–β-catenin complex in the nucleus. * Author for correspondence ( leo.serebryannyy@nih.gov ) Competing interests The authors declare no competing or financial interests. 18 11...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (4): 805–813.
Published: 15 February 2017
... such oncogene, Musashi-1 ( Msi-1 ), regulates translation of target mRNAs and is implicated in promoting tumorigenesis in the colon and other tissues. Msi-1 targets include the tumor suppressor adenomatous polyposis coli ( Apc ), a Wnt pathway antagonist lost in ∼80% of all colorectal cancers. Cell culture...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 983–993.
Published: 1 March 2016
...Austin T. Baldwin; Amy M. Clemons; Bryan T. Phillips ABSTRACT The Wnt/β-catenin signaling pathway is utilized across metazoans. However, the mechanism of signal transduction, especially dissociation of the β-catenin destruction complex by Dishevelled proteins, remains controversial. Here, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 665–672.
Published: 15 February 2016
...Eliana Stanganello; Steffen Scholpp ABSTRACT Wnt signaling regulates a broad variety of processes during embryonic development and disease. A hallmark of the Wnt signaling pathway is the formation of concentration gradients by Wnt proteins across responsive tissues, which determines cell fate...
Journal Articles
J Cell Sci (2015) 128 (24): 4499–4511.
Published: 15 December 2015
...Eric T. Hall; Esther M. Verheyen ABSTRACT Wnt/Wingless (Wg) and Ras–MAPK signaling both play fundamental roles in growth and cell fate determination, and when dysregulated, can lead to tumorigenesis. Several conflicting modes of interaction between Ras–MAPK and Wnt signaling have been identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2430–2436.
Published: 15 July 2015
...Bin Ma; Monika Fey; Michael O. Hottiger ABSTRACT The discovery of functional crosstalk between WNT and nuclear factor κB (NF-κB) signaling has established a more complex role for these two pathways in inflammation and cancer. However, the molecular mechanisms of the crosstalk and its biological...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2156–2168.
Published: 1 June 2015
... phosphorylation, thereby inhibiting EGF signaling in keratinocytes ( Xu et al., 2010 ). In addition, there is crosstalk between Wnt and TGF-β signaling; for example, it has been shown that TGF-β upregulates Tcf4 and increases Tcf4 transcriptional activity during osteoblast maturation ( McCarthy and Centrella...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1408–1421.
Published: 1 April 2015
...Simon W. Fellgett; Richard J. Maguire; Mary Elizabeth Pownall ABSTRACT Wnt signalling plays essential roles during embryonic development and is known to be mis-regulated in human disease. There are many molecular mechanisms that ensure tight regulation of Wnt activity. One such regulator...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (6): 1139–1149.
Published: 15 March 2015
... ventrally to contribute to most of the facial structures including bones, cartilage, muscles and ganglia. ADAM13 is a cell surface metalloprotease that is essential for CNC cell migration. Here, we show in Xenopus laevis embryos that the Wnt receptor Fz4 binds to the cysteine-rich domain of ADAM13...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 33–39.
Published: 1 January 2015
...Dominic B. Bernkopf; Michel V. Hadjihannas; Jürgen Behrens ABSTRACT Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated...
Includes: Supplementary data
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Journal Articles
Journal Articles