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Keywords: VEGFR2
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Journal Articles
Journal Articles
J Cell Sci (2023) 136 (2): jcs260270.
Published: 27 January 2023
... cells (GECs) in a dose-dependent manner and inhibits the angiogenesis of GECs. p53 and RNA-binding motif protein 4 (RBM4) were expressed at low levels in GECs, while MDM2 and vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR) were highly expressed. In vitro and in vivo experiments...
Includes: Supplementary data
Journal Articles
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Cell migration
J Cell Sci (2019) 132 (20): jcs232645.
Published: 28 October 2019
...Oisun Jung; DeannaLee M. Beauvais; Kristin M. Adams; Alan C. Rapraeger ABSTRACT When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2014) 127 (20): 4518–4530.
Published: 15 October 2014
...Kaori H. Yamada; Yuki Nakajima; Melissa Geyer; Kishore K. Wary; Masuko Ushio-Fukai; Yulia Komarova; Asrar B. Malik ABSTRACT Although the trafficking of newly synthesized VEGFR2 to the plasma membrane is a key determinant of angiogenesis, the molecular mechanisms of Golgi to plasma membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (4): 831–843.
Published: 15 February 2012
... and increases VEGF expression, which is mediated by the induction of Krüppel-like factor 2 (KLF2). Additionally, shear stress stimulates the expression of VEGF receptor 2 (VEGFR2) and is associated with its activation. Knockdown of VEGF in shear stressed HUVECs blocks the protective effect of shear stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (24): 4221–4230.
Published: 15 December 2010
...-phosphorylated upon VEGF treatment in a SHP-1- and Src-dependent manner, and that the key residues of the long cytoplasmic domain of CEACAM1 are crucial for CEACAM1 phosphorylation and NO production. This data represents the first report, to our knowledge, of a functional link between CEACAM1 and the VEGFR2/Akt...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1684–1692.
Published: 15 May 2010
... ) 25 2 2010 © 2010. 2010 Embryonic stem cell Allantois Tumor angiogenesis Pancreatic cancer VEGFR2 Tie2 Blood vessels consist of a lining of endothelial cells surrounded by mural cells (pericytes and vascular smooth muscle cells), and play essential roles in the maintenance...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (21): 3570–3580.
Published: 1 November 2008
... prevent excessive and harmful angiogenesis are not well understood. Here, our objective was to study whether T-cell protein tyrosine phosphatase (TCPTP, also known as PTN2), which we found to be expressed in human endothelial cells, could alter VEGF signalling by controlling phosphorylation of VEGFR2. We...
Includes: Supplementary data