...-directed differentiation . Science   341 , 1240104 . 10.1126/science.1240104 Tao , L. , Huang , G. , Song , H. , Chen , Y. and Chen , L. ( 2017 ). Cancer associated fibroblasts: an essential role in the tumor microenvironment . Oncol. Lett.   14 , 2611 - 2620 . 10.3892...

.... * Authors for correspondence ( sukharev@umd.edu ; sachs@buffalo.edu ) © 2012. Published by The Company of Biologists Ltd 2012 Activin Cancer Tumor microenvironment Wound healing Cells and tissues respond to a variety of mechanical stresses that can be roughly classified as follows: (1...

...Jiewei Liu; Kun Xu; Maya Chase; Yuxin Ji; Jennifer K. Logan; Rachel J. Buchsbaum The tumor microenvironment undergoes changes concurrent with neoplastic progression. Cancer incidence increases with aging and is associated with tissue accumulation of senescent cells. Senescent fibroblasts...

.... * Author for correspondence ( cho1988@yuhs.ac ) 1 7 2010 © 2010. 2010 Breast carcinoma Epithelial-mesenchymal transition Stromal fibroblasts Tumor zones Tumor microenvironment Interface fibroblasts Breast cancer is a major health problem that affects the lives of millions...

..., suggesting that pro-cath-D–LRP1β interaction plays a functional role in the outgrowth of fibroblasts. Overall, our findings strongly suggest that pro-cath-D secreted by epithelial cancer cells promotes fibroblast outgrowth in a paracrine LRP1-dependent manner in the breast tumor microenvironment. RNA...

... release of growth factors and cytokines, the tumor microenvironment can mediate tumor-cell survival, tumor proliferation and regulation of the immune response. Moreover, by conferring cancer cells with an enhanced ability to migrate and invade adjacent tissues, extracellular regulatory signals can play...