... tracheal respiratory system of Drosophila embryos. Tubulogenesis Epithelial tube fusion Extracellular vesicle Multivesicular body Rab GTPases Drosophila Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 SFB 1348 EXC 1003 SFB 1009 Westfälische...

... methods for interrogating the initiation of ADPKD cystogenesis. 3D cell model Epithelia Kidney Tubulogenesis Collecting duct Polycystic kidney disease In vitro models of stem cell differentiation and kidney development have set the stage for expanding our understanding...

... degradation, mechanical properties, and adhesive ligand type and density to study the impact of ECM properties on epithelial tubulogenesis for inner medullary collecting duct (IMCD) cells. Protease sensitivity of the synthetic material for membrane-type matrix metalloproteinase-1 (MT1-MMP, also known as MMP14...

...Souji Ibuka; Shinji Matsumoto; Shinsuke Fujii; Akira Kikuchi ABSTRACT Epithelial tubular structures are essential units in various organs. Here, we used rat intestinal epithelial IEC6 cells to investigate tubulogenesis and we found that tubular formation was induced by a combination of Wnt3a...

...Sarah A. Weaver; Brit Wolters; Noriko Ito; Anna M. Woskowicz; Kazuyo Kaneko; Yasuyuki Shitomi; Motoharu Seiki; Yoshifumi Itoh ABSTRACT The membrane-anchored collagenase membrane type 1 matrix metalloprotease (MT1-MMP) has been shown to play an essential role during epithelial tubulogenesis in 3D...

... is defective. * Author for correspondence ( Markus.Affolter@unibas.ch ) 18 10 2012 © 2012. Published by The Company of Biologists Ltd 2012 Tubulogenesis Trachea Lumen expansion Unicellular tubes Tubular epithelial structures are present in different animal organs...

...) Intracellular trafficking Lipid homeostasis Secretory pathway Tubulogenesis Tube formation in multicellular organisms depends on the ability of epithelial cells to polarize and to form basal and apical membrane compartments de novo. During tube maturation, the initially narrow lumen, formed...

... signaling associated with hepatocyte growth factor (HGF)-mediated scattering and tubulogenesis of MDCK cells revealed that 3D culture modulates cellular responses both through dimensionality and altered stimulation rates. Comparing responses in 2D culture, microgels and macrogels demonstrated that HGF...

..., T. A., Rocchi, S., Van Obberghen, E. and Comoglio, P. M. ( 2000 ). Sustained recruitment of phospholipase C-γ to Gαβ1 is required for HGF-induced branching tubulogenesis. Oncogene 19 , 1509 -1518. Guha, M., Zhou, M. and Wang, Y. L. ( 2005 ). Cortical actin turnover during cytokinesis...

... growth factor and hepatocyte growth factor stimulated the formation of transporting tubules. The stimulatory effect of both epidermal growth factor and hepatocyte growth factor on tubulogenesis was inhibited by PD98059, a mitogen activated protein kinase kinase inhibitor, rather than by wortmannin...

... can modulate HGF/SF-induced scattering and tubulogenesis in MDCK II cells. MDCK type II cells were grown in modified Dulbecco Eagle”s medium (DMEM) containing Earle's balanced salt solution supplemented with 5% fetal bovine serum, 100 U/ml penicillin, 100 μg/ml streptomycin, and 0.25 mg/ml...

... factor-2 (FGF-2),hepatocyte growth factor/scatter factor (HGF/SF) and an angiogenic cocktail composed of nine angiogenic factors. Endothelial tubulogenesis was also increased in co-culture with tumour cells such as U87 glioma cells, but not with non-tumorigenic cell types such as Madin-Darby canine...