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Keywords: Trypanosoma brucei
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Journal Articles
J Cell Sci (2022) 135 (11): jcs259893.
Published: 9 June 2022
...Miharisoa Rijatiana Ramanantsalama; Nicolas Landrein; Elina Casas; Bénédicte Salin; Corinne Blancard; Mélanie Bonhivers; Derrick R. Robinson; Denis Dacheux ABSTRACT In Trypanosoma brucei , transition fibres (TFs) form a nine-bladed pattern-like structure connecting the base of the flagellum...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs254300.
Published: 8 March 2021
...Simona Amodeo; Ana Kalichava; Albert Fradera-Sola; Eloïse Bertiaux-Lequoy; Paul Guichard; Falk Butter; Torsten Ochsenreiter ABSTRACT Proper mitochondrial genome inheritance is important for eukaryotic cell survival. Trypanosoma brucei , a protozoan parasite, contains a singular mitochondrial genome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs248047.
Published: 15 September 2020
...Jana Jentzsch; Adal Sabri; Konstantin Speckner; Gertrud Lallinger-Kube; Matthias Weiss; Klaus Ersfeld ABSTRACT The shape of kinetoplastids, such as Trypanosoma brucei , is precisely defined during the stages of the life cycle and governed by a stable subpellicular microtubule cytoskeleton. During...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs129213.
Published: 9 July 2020
...Robert L. Douglas; Brett M. Haltiwanger; Anna Albisetti; Haiming Wu; Robert L. Jeng; Joel Mancuso; W. Zacheus Cande; Matthew D. Welch ABSTRACT Trypanosoma brucei , the causative agent of African sleeping sickness, has a flagellum that is crucial for motility, pathogenicity, and viability. In most...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (11): jcs245258.
Published: 11 June 2020
...Tai An; Qing Zhou; Huiqing Hu; Harshini Cormaty; Ziyin Li ABSTRACT The human parasite Trypanosoma brucei transitions from the trypomastigote form to the epimastigote form in the insect vector by repositioning its mitochondrial genome and flagellum-associated cytoskeleton. The molecular mechanisms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs233072.
Published: 7 May 2020
...Jonathan C. Miller; Stephanie B. Delzell; Jeniffer Concepción-Acevedo; Michael J. Boucher; Michele M. Klingbeil ABSTRACT Mitochondrial DNA of Trypanosoma brucei and related parasites is a catenated network containing thousands of minicircles and tens of maxicircles, called kinetoplast DNA (kDNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs240978.
Published: 29 April 2020
...Midori Ishii; Bungo Akiyoshi ABSTRACT The kinetochore is a macromolecular protein complex that drives chromosome segregation in eukaryotes. Unlike most eukaryotes that have canonical kinetochore proteins, evolutionarily divergent kinetoplastids, such as Trypanosoma brucei , have unconventional...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (14): jcs230581.
Published: 15 July 2019
...Kieu T. M. Pham; Qing Zhou; Yasuhiro Kurasawa; Ziyin Li ABSTRACT Trypanosoma brucei possesses a motile flagellum that determines cell morphology and the cell division plane. Inheritance of the newly assembled flagellum during the cell cycle is controlled by the Polo-like kinase homolog TbPLK, which...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (17): jcs219071.
Published: 5 September 2018
...-exchange factor (GEF) for Arl3 and is implicated in a variety of ciliary and cellular functions. We have identified and characterized Trypanosoma brucei (Tb)Arl13, the sole Arl13b homolog in this evolutionarily divergent, protozoan parasite . TbArl13 has conserved flagellar functions and exhibits catalytic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (9): jcs206417.
Published: 10 May 2018
... against cellular stresses and apoptosis, indicating the multifunctional role of the protein. Here, for the first time, we characterize the expression and function of TCTP in the human and animal pathogen, Trypanosoma brucei . We identified two paralogs ( TCTP1 and TCTP2 ) that are differentially expressed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs211730.
Published: 25 April 2018
...Simona Amodeo; Martin Jakob; Torsten Ochsenreiter ABSTRACT The unicellular parasite Trypanosoma brucei harbors one mitochondrial organelle with a singular genome called the kinetoplast DNA (kDNA). The kDNA consists of a network of concatenated minicircles and a few maxicircles that form the kDNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4108–4119.
Published: 15 December 2017
....2007.11.011 Benz , C. and Clayton , C. E. ( 2007 ). The F-box protein CFB2 is required for cytokinesis of bloodstream-form Trypanosoma brucei . Mol. Biochem. Parasitol.   156 , 217 - 224 . 10.1016/j.molbiopara.2007.08.005 Benz , C. , Clucas , C. , Mottram , J. C...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (22): 3918–3932.
Published: 15 November 2017
...Amy N. Sinclair-Davis; Michael R. McAllaster; Christopher L. de Graffenried ABSTRACT The parasite Trypanosoma brucei is highly polarized, including a flagellum that is attached along the cell surface by the flagellum attachment zone (FAZ). During cell division, the new FAZ positions the cleavage...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (4): 854–867.
Published: 15 February 2016
... revealed a precisely defined 3D organisation for both the flagellar pocket and FAZ, with striking similarities to those of Trypanosoma brucei . Expression of two T. brucei FAZ proteins in L. mexicana showed that T. brucei FAZ proteins can assemble into the Leishmania FAZ structure. Leishmania therefore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (13): 2361–2372.
Published: 1 July 2015
...Qing Zhou; Huiqing Hu; Cynthia Y. He; Ziyin Li ABSTRACT Adhesion of motile flagella to the cell body in Trypanosoma brucei requires a filamentous cytoskeletal structure termed the flagellum attachment zone (FAZ). Despite its essentiality, the complete molecular composition of the FAZ filament...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2351–2364.
Published: 15 May 2014
... that is highly enriched in, and present throughout, the plasma membrane – has been implicated in endocytosis. Trypanosoma brucei has one of the highest known rates of endocytosis, a process it uses to evade the immune system. To determine whether phosphoinositides play a role in endocytosis in this organism, we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 204–215.
Published: 1 January 2014
...Brice Rotureau; Thierry Blisnick; Ines Subota; Daria Julkowska; Nadège Cayet; Sylvie Perrot; Philippe Bastin ABSTRACT The Trypanosoma brucei flagellum is an essential organelle anchored along the surface of the cell body through a specialized structure called the flagellum attachment zone (FAZ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5748–5757.
Published: 15 December 2013
...Louise Hughes; Katie Towers; Tobias Starborg; Keith Gull; Sue Vaughan Summary Flagella are highly conserved organelles present in a wide variety of species. In Trypanosoma brucei the single flagellum is necessary for morphogenesis, cell motility and pathogenesis, and is attached along the cell body...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (10): 2294–2304.
Published: 15 May 2013
... and all further distributions of the work or adaptation are subject to the same Creative Commons License terms. Differentiation Gene expression Trypanosoma brucei References Barnwell   E. M. , van Deursen   F. J. , Jeacock   L. , Smith   K. A. , Maizels   R. M...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 520–531.
Published: 15 January 2013
..., transmembrane protein essential for flagellum attachment and cell division. By immunoprecipitation of a FLA1-truncation mutant that mislocalized to the flagellum, a novel FLA1-binding protein (FLA1BP) was identified in procyclic Trypanosoma brucei . The interaction between FLA1 on the cell membrane and FLA1BP...
Includes: Supplementary data