...Magdalena Adamczyk; Rhiannon Griffiths; Sharon Dewitt; Vera Knäuper; Daniel Aeschlimann ABSTRACT Transglutaminases (denoted TG or TGM) are externalized from cells via an unknown unconventional secretory pathway. Here, we show for the first time that purinergic signaling regulates active secretion...

...Evgeny A. Zemskov; Irina Mikhailenko; Dudley K. Strickland; Alexey M. Belkin Tissue transglutaminase functions as a protein crosslinking enzyme and an integrin-binding adhesion co-receptor for fibronectin on the cell surface. These activities of transglutaminase and the involvement of this protein...

...Phil Stephens; Pascale Grenard; Pascale Aeschlimann; Martin Langley; Emma Blain; Rachael Errington; David Kipling; David Thomas; Daniel Aeschlimann Tissue transglutaminase (TG2) affects cell-matrix interactions in cell spreading, migration and extracellular matrix (ECM) reorganisation. Using...

... keratinocytes in both stratified organotypic cultures and in mouse skin during epidermal barrier repair. Treatment of cultured keratinocytes with exogenous cathepsin D increased the activity of transglutaminase 1, known to cross-link the cornified envelope proteins involucrin and loricrin during epidermal...