..., for the first time, demonstrate that carcinoma cells can induce sE-cad shedding in adjacent epithelial cells, which leads to EGFR activation and the eventual transdifferentiation of the normal epithelial cells. * Author for correspondence ( raj@therapyarchitects.com ) Competing interests The authors...

.... , Cooney   G. J. , Kraegen   E. W. ( 2003 ). The role of intramuscular lipid in insulin resistance.   Acta Physiol. Scand.   178 , 373 – 383 . 10.1046/j.1365-201X.2003.01162.x Hu   E. , Tontonoz   P. , Spiegelman   B. M. ( 1995 ). Transdifferentiation of myoblasts...

...-u.ac.jp © 2012. 2012 Cell fate Reprogramming Transdifferentiation Differentiation has long been thought of as a one-way street that is representative of a downhill progression from an undifferentiated stem or progenitor cell state to a physiologically mature cell, as imagined...

... 2005 2005 Bone-marrow-derived stem cells Neurogenesis Transdifferentiation The notion that phenotypic fate is indissolubly bound to the embryonic germ layer derivation of the cell has been challenged by several observations on different types of pluripotent stem cells. A number...

...-dresden.de ) * Authors contributed equally 5 5 2004 © The Company of Biologists Limited 2004 2004 Mesodermal stromal cells Neural stem cells Transdifferentiation Neural differentiation Human stem cells Tissue-specific stem cells were thought to be lineage restricted...

... that have led to this state of affairs have included the inability to reproduce certain widely quoted data, one case where the apparent transdifferentiation was due to contamination of the donor tissue with haematopoietic cells and, most notoriously, extrapolating from the behaviour of embryonic stem cells...

... Neural differentiation Neural progenitors Transdifferentiation Long-standing dogma states that neural stem cells with the ability to differentiate into neurons, astrocytes and oligodendrocytes are derived embryologically from neuroepithelial progenitors. However, several studies from different...