..., for the first time, demonstrate that carcinoma cells can induce sE-cad shedding in adjacent epithelial cells, which leads to EGFR activation and the eventual transdifferentiation of the normal epithelial cells. * Author for correspondence ( raj@therapyarchitects.com ) Competing interests The authors...

... cells Transdifferentiation The essential role of satellite cells ( Mauro, 1961 ) in muscle regeneration is well known ( Lepper et al., 2011 ; Sambasivan et al., 2011 ), but these cells have also been proposed as the source of fat accumulation in mouse ( Grimaldi et al., 1997 ; Asakura et al...

... it originated. It is still unclear whether several different paths to the top exist for any particular fate. However, it now appears that transdifferentiation, or direct reprogramming, effectively lowers the force of gravity on this landscape, and allows cells to move from one valley to another with relative...

... 2005 2005 Bone-marrow-derived stem cells Neurogenesis Transdifferentiation The notion that phenotypic fate is indissolubly bound to the embryonic germ layer derivation of the cell has been challenged by several observations on different types of pluripotent stem cells. A number...

... contributed equally 5 5 2004 © The Company of Biologists Limited 2004 2004 Mesodermal stromal cells Neural stem cells Transdifferentiation Neural differentiation Human stem cells Tissue-specific stem cells were thought to be lineage restricted and therefore only able...

... that have led to this state of affairs have included the inability to reproduce certain widely quoted data, one case where the apparent transdifferentiation was due to contamination of the donor tissue with haematopoietic cells and, most notoriously, extrapolating from the behaviour of embryonic stem cells...

... to neural fate in tissues other than neuroectodermal. Human stem cells Cord blood Neural differentiation Neural progenitors Transdifferentiation © The Company of Biologists Limited 2002 2002 20 2 2002 * Author for correspondence (e-mail: kd-j@cmdik.pan.pl ) Mixed...

...Ester Piek; Aristidis Moustakas; Akira Kurisaki; Carl-Henrik Heldin; Peter ten Dijke ABSTRACT The capacities of different transforming growth factor-β (TGF-β) superfamily members to drive epithelial to mesenchymal transdifferentiation of the murine mammary epithelial cell line NMuMG were...