...; generically referred to as CtBP1/2) as components of the PRDM14-mediated repressive complex. CtBP1/2 binding to PRDM14 depends on CBFA2T2, a core component of the PRDM14 complex. The loss of Ctbp1/2 impaired the PRDM14-mediated transcriptional repression required for pluripotency maintenance and transition...

... HIFα Hypoxia PHD EGLN SUMO Transcriptional repression Maintaining oxygen homeostasis is essential for most organisms as hypoxia, even when transient, could trigger irreversible damage. Adaptation to reduced oxygen availability is indeed a major physiological challenge during embryonic...

... . Capicua Cell proliferation CIC MAPK RTK signaling Transcriptional repression Tumor suppressor Receptor tyrosine kinase (RTK) signaling pathways regulate many biological processes in all metazoans. Their activities elicit diverse cellular responses, such as proliferation, differentiation...

... in the nucleus. These results identify a stress-induced proteolytic pathway regulating cyclin C that requires nuclear to cytoplasmic relocalization and Not4p-mediated ubiquitylation. Mediator complex Oxidative stress Transcriptional repression Ubiquitin protein degradation * Author...

... locus, we have been able to demonstrate that BEND3 associates with the locus only when it is heterochromatic and dissociates upon activation of transcription. Furthermore, tethering BEND3 inhibits transcription from the locus, indicating that BEND3 is involved in transcriptional repression through its...

... to pericentric heterochromatin and KAKA foci, and suggest that KAKA foci may contain sumoylated KAP1 – the form of the protein that is active in transcriptional repression. We have previously described how a gene-trap screen (which uses an ATG- and promoter-less gene-trap vector, and relies on in-frame...

...Mehrnaz Fatemi; Paul A. Wade Methylation of DNA in mammalian cells serves to demarcate functionally specialized regions of the genome and is strongly associated with transcriptional repression. A highly conserved family of DNA-binding proteins characterized by a common sequence motif is widely...

... ). Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 293 , 1653 -1657. Cohen, M., Lee, K. K., Wilson, K. L. and Gruenbaum, Y. ( 2001 ). Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina. Trends Biochem. Sci. 26...

...-specific Kaiso-binding-site fusion with luciferase as reporter demonstrated that the identified NLS was crucial for Kaiso-mediated transcriptional repression. The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes...

... ctn was to regulate Kaiso-mediated transcriptional repression. However, it remained unclear whether p120 ctn sequestered Kaiso in the cytosol or directly inhibited Kaiso transcriptional activity in the nucleus. Using minimal promoter assays, we show here that the regulatory effect of p120 ctn on Kaiso...

... of Genetics & Development, Columbia University, 701 West 168th Street, New York, NY 10032, USA 6 8 2003 © The Company of Biologists Limited 2003 2003 Cardiomyocytes Transcriptional repression Transgenic mice The establishment and maintenance of transcriptional diversity...

... nuclear factor κB (NF-κB)- and E2F1- regulated targets. Thus, depletion of DAXX by RNAi has verified the crucial role of endogenous DAXX as an anti-apoptotic regulator, and has allowed the identification of probable physiological targets of DAXX transcriptional repression. In this report, we have used...

... into genitourinary evolution. Key words: W ilm s tum our, W TI, transcriptional repression, tum our suppression, zinc finger known transcription factors SP1, EGR1 (krox24) and EGR2 (krox20). Unlike these other zinc finger proteins four different isoforms of W TI are produced through two alternative splices, one...

...RICHARD MEEHAN; JOE LEWIS; SALLY CROSS; XINSHENG NAN; PETER JEPPESEN; ADRIAN BIRD Summary Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA...