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Keywords: Transcriptional repression
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Journal Articles
Journal Articles
J Cell Sci (2015) 128 (1): 40–49.
Published: 1 January 2015
... SUMO Transcriptional repression Maintaining oxygen homeostasis is essential for most organisms as hypoxia, even when transient, could trigger irreversible damage. Adaptation to reduced oxygen availability is indeed a major physiological challenge during embryonic development and in adulthood...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (6): 1383–1391.
Published: 15 March 2012
... of these findings for our understanding of RTK signaling specificity in different biological processes. * Author for correspondence ( gjcbmc@ibmb.csic.es ) © 2012. 2012 Capicua Cell proliferation CIC MAPK RTK signaling Transcriptional repression Tumor suppressor Receptor tyrosine kinase...
Journal Articles
J Cell Sci (2012) 125 (4): 1015–1026.
Published: 15 February 2012
... stress Transcriptional repression Ubiquitin protein degradation Exposure to environmental stress induces extensive remodeling of the transcriptome (reviewed by Mager and De Kruijff, 1995 ). The yeast cyclin-C–Cdk8p kinase complex is a highly conserved negative transcriptional regulator of many...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3149–3163.
Published: 15 September 2011
... locus, we have been able to demonstrate that BEND3 associates with the locus only when it is heterochromatic and dissociates upon activation of transcription. Furthermore, tethering BEND3 inhibits transcription from the locus, indicating that BEND3 is involved in transcriptional repression through its...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 937–946.
Published: 1 April 2009
... to pericentric heterochromatin and KAKA foci, and suggest that KAKA foci may contain sumoylated KAP1 – the form of the protein that is active in transcriptional repression. ‡ Author for correspondence (e-mail: h.sutherland@hgu.mrc.ac.uk ) * These authors contributed equally to this work 19...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (15): 3033–3037.
Published: 1 August 2006
...Mehrnaz Fatemi; Paul A. Wade Methylation of DNA in mammalian cells serves to demarcate functionally specialized regions of the genome and is strongly associated with transcriptional repression. A highly conserved family of DNA-binding proteins characterized by a common sequence motif is widely...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (25): 6143–6152.
Published: 1 December 2004
...-specific Kaiso-binding-site fusion with luciferase as reporter demonstrated that the identified NLS was crucial for Kaiso-mediated transcriptional repression. The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (2): 345–352.
Published: 15 January 2003
... nuclear factor κB (NF-κB)- and E2F1- regulated targets. Thus, depletion of DAXX by RNAi has verified the crucial role of endogenous DAXX as an anti-apoptotic regulator, and has allowed the identification of probable physiological targets of DAXX transcriptional repression. Cells were grown in DMEM...
Journal Articles
J Cell Sci (2000) 113 (24): 4463–4474.
Published: 15 December 2000
... by Company of Biologists 2000 Nucleolus Chromatin Methylation Transcriptional repression rRNA Eukaryotic interphase nuclei are highly compartmentalised structures. It is generally accepted that architectural organisation of the nucleus and regulation of transcription are functionally...
Journal Articles
J Cell Sci (1992) 1992 (Supplement_16): 9–14.
Published: 1 January 1992
...Richard Meehan; Joe Lewis; Sally Cross; Xinsheng Nan; Peter Jeppesen; Adrian Bird ABSTRACT Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA...