...; generically referred to as CtBP1/2) as components of the PRDM14-mediated repressive complex. CtBP1/2 binding to PRDM14 depends on CBFA2T2, a core component of the PRDM14 complex. The loss of Ctbp1/2 impaired the PRDM14-mediated transcriptional repression required for pluripotency maintenance and transition...

... SUMO Transcriptional repression Maintaining oxygen homeostasis is essential for most organisms as hypoxia, even when transient, could trigger irreversible damage. Adaptation to reduced oxygen availability is indeed a major physiological challenge during embryonic development and in adulthood...

... of these findings for our understanding of RTK signaling specificity in different biological processes. * Author for correspondence ( gjcbmc@ibmb.csic.es ) © 2012. 2012 Capicua Cell proliferation CIC MAPK RTK signaling Transcriptional repression Tumor suppressor Receptor tyrosine kinase...

... stress Transcriptional repression Ubiquitin protein degradation Exposure to environmental stress induces extensive remodeling of the transcriptome (reviewed by Mager and De Kruijff, 1995 ). The yeast cyclin-C–Cdk8p kinase complex is a highly conserved negative transcriptional regulator of many...

... locus, we have been able to demonstrate that BEND3 associates with the locus only when it is heterochromatic and dissociates upon activation of transcription. Furthermore, tethering BEND3 inhibits transcription from the locus, indicating that BEND3 is involved in transcriptional repression through its...

... to pericentric heterochromatin and KAKA foci, and suggest that KAKA foci may contain sumoylated KAP1 – the form of the protein that is active in transcriptional repression. ‡ Author for correspondence (e-mail: h.sutherland@hgu.mrc.ac.uk ) * These authors contributed equally to this work 19...

...Mehrnaz Fatemi; Paul A. Wade Methylation of DNA in mammalian cells serves to demarcate functionally specialized regions of the genome and is strongly associated with transcriptional repression. A highly conserved family of DNA-binding proteins characterized by a common sequence motif is widely...

... ). Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 293 , 1653 -1657. Cohen, M., Lee, K. K., Wilson, K. L. and Gruenbaum, Y. ( 2001 ). Transcriptional repression, apoptosis, human disease and the functional evolution of the nuclear lamina. Trends Biochem. Sci. 26...

...-specific Kaiso-binding-site fusion with luciferase as reporter demonstrated that the identified NLS was crucial for Kaiso-mediated transcriptional repression. The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes...

... ctn was to regulate Kaiso-mediated transcriptional repression. However, it remained unclear whether p120 ctn sequestered Kaiso in the cytosol or directly inhibited Kaiso transcriptional activity in the nucleus. Using minimal promoter assays, we show here that the regulatory effect of p120 ctn on Kaiso...

... cardiomyocytes is maintained by a cell-autonomous mechanism that is dependent on developmental cell history. Transcriptional repression has been shown to be associated with hypermethylation ( Newell-Price et al., 2000 ). We investigated the methylation status of the Mlc3f-nlacZ-2E transgene in different...

... nuclear factor κB (NF-κB)- and E2F1- regulated targets. Thus, depletion of DAXX by RNAi has verified the crucial role of endogenous DAXX as an anti-apoptotic regulator, and has allowed the identification of probable physiological targets of DAXX transcriptional repression. Cells were grown in DMEM...

... by Company of Biologists 2000 Nucleolus Chromatin Methylation Transcriptional repression rRNA Eukaryotic interphase nuclei are highly compartmentalised structures. It is generally accepted that architectural organisation of the nucleus and regulation of transcription are functionally...

... into genitourinary evolution. Key words: W ilm s tum our, W TI, transcriptional repression, tum our suppression, zinc finger known transcription factors SP1, EGR1 (krox24) and EGR2 (krox20). Unlike these other zinc finger proteins four different isoforms of W TI are produced through two alternative splices, one...

...RICHARD MEEHAN; JOE LEWIS; SALLY CROSS; XINSHENG NAN; PETER JEPPESEN; ADRIAN BIRD Summary Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA...