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Keywords: Transcription
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Journal Articles
J Cell Sci (2022) 135 (8): jcs259972.
Published: 26 April 2022
... transcriptional partners. However, the network of factors that controls SMAD2 chromatin binding and shapes its transcriptional programme over time is poorly characterised. Here, we combine ATAC-seq with computational footprinting to identify temporal changes in chromatin accessibility and transcription factor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs258818.
Published: 26 January 2022
... to wild-type data, uncoupling Hi-C-measured long-range DNA contacts from transcriptional repression of the X chromosomes. Taken together, our results indicate that DPY-21 has a non-catalytic role in regulating the dynamics of condensin DC binding, which is important for transcription repression...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs259097.
Published: 12 January 2022
.... References Alarcon , C. , Zaromytidou , A. I. , Xi , Q. , Gao , S. , Yu , J. , Fujisawa , S. , Barlas , A. , Miller , A. N. , Manova-Todorova , K. , Macias , M. J. et al. ( 2009 ). Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs259051.
Published: 5 August 2021
... acetylation of histone H3K56. Acetylation at this site is important to allow access to chromatin after DNA damage, enhance histone turnover at transcriptionally active chromatin, and to promote nucleosome assembly during S phase ( Kaplan et al., 2008 ; Li et al., 2008 ; Topal et al., 2019 ; Wurtele et al...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (11): jcs258338.
Published: 4 June 2021
...: a novel mode of toxic cadmium action in vivo . Curr. Genet. 64 , 177 - 181 . 10.1007/s00294-017-0748-x Thomas , B. J. and Rothstein , R. ( 1989 ). Elevated recombination rates in transcriptionally active DNA . Cell 56 , 619 - 630 . 10.1016/0092-8674(89)90584-9...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (5): jcs252544.
Published: 9 November 2020
... early in infection remained unexplained. We thus assessed the amount of transcriptionally active nuclear vDNA. Cellular gene loci active in transcription have been visualized using RNA FISH targeting intron sequences ( Levesque and Raj, 2013 ; Shah et al., 2018 ), or by monitoring transcriptional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs242420.
Published: 4 June 2020
...-mRNA processing ( Majewski et al., 2018 ). This, together with its localisation on promyelocytic leukaemia protein (PML) nuclear bodies ( Majewski et al., 2018 ), which consist of chromatin and transcription activators, suggests that MVI is present in a number of transcriptionally active areas...
Journal Articles
J Cell Sci (2020) 133 (4): jcs236265.
Published: 21 February 2020
... of misfolded proteins upon thermal stress ( Richter et al., 2010 ). This network is highly important for the immediate activation of the heat-shock response ( Velichko et al., 2013 ). The Hsp70 gene locus is transcriptionally activated upon heat shock and shows enhanced contacts with nuclear speckles, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (21): jcs238402.
Published: 1 November 2019
... are transcriptionally upregulated during stress, and importantly, TFs can bind to both promoters and enhancers to regulate stress-induced gene transcription ( Maruyama et al., 2014 ; Vihervaara et al., 2017 ; Grossi et al., 2018 ; Lyu et al., 2018 ). However, the impact of enhancers on genome-wide and stress...
Journal Articles
J Cell Sci (2019) 132 (8): jcs226852.
Published: 17 April 2019
... elongation or pausing rate. Extensive previous work has established that the bulk of cellular pre-mRNA splicing takes place co-transcriptionally, but has also shown that the elongation and pausing rates of Pol II can influence alternative splicing decisions ( Herzel et al., 2017 ). Specifically, our data...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (3): jcs220491.
Published: 7 February 2019
... and chromatin-remodeling factors that migrate along DNA. In terms of genome biology, the term compartment is narrowly defined: compartments are untethered, but self-interacting domains of transcriptionally active (open or A domains) or repressed (closed or B domains) chromatin states that may contain 5 to 50...
Journal Articles
J Cell Sci (2019) 132 (3): jcs222729.
Published: 7 February 2019
.... Thus, these data imply that phosphorylated Pol II preferentially recruits HP1c proteins at the transcriptionally active chromatin region, and HP1b may be recruited through forming heterodimers with HP1c at the region. Taken together, these data indicate that HP1b and HP1c may counteract HP1a function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (2): jcs224055.
Published: 18 January 2019
... is also regulated by Upf1 at the level of transcription. We first analyzed Arc mRNA and pre-mRNA levels in Upf1 knockdown and KO cells by qRT-PCR and found that these did not differ significantly ( Figs 1 C,D and 2 B–D), strongly suggesting that Arc mRNA is transcriptionally modulated. The Arc...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs210971.
Published: 22 October 2018
... named Spooki 1.0 mCherry was generated that expresses mCherry under the control of Spooki 1.0 in a transcriptionally silent region of chromosome 12 ( Fig. 2 A; Fig. S1 ). Live-cell imaging of Spooki 1.0 mCherry ookinetes, oocysts, salivary gland (SG) sporozoites and liver stages revealed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (18): jcs220251.
Published: 20 September 2018
...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213967.
Published: 5 June 2018
... each treatment were used to measure the cell size and cell fusion index. Values are means±s.e.m. We assessed whether RANKL-mediated adseverin expression was regulated transcriptionally by conducting adseverin promoter activity assays. Briefly, a 2 kb genomic DNA fragment ( Fig. 4 A) upstream...
Journal Articles
J Cell Sci (2018) 131 (9): jcs211631.
Published: 8 May 2018
... occurs during the pre-MBT, we expected to observe core and CAK colocalization in transcriptionally active nuclei in pre-MBT embryos (i.e. at the interphase of NC8 and onwards). However, in addition to the nuclear localization of TFIIH core subunits during interphase, in this study, we noted some nuclear...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (12): 2049–2055.
Published: 15 June 2017
... signalling. Sck2 had the greatest effect on cell growth, and we also show that it significantly increases the cellular transcription rate. These findings indicate, for the first time, that global transcriptional control mediated through S6 kinase signalling is central to cellular growth control...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (24): 4534–4547.
Published: 15 December 2016
... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (18): 3412–3425.
Published: 15 September 2016
... and activity of the SRF cofactor MAL . Science   316 , 1749 - 1752 . 10.1126/science.1141084 Wang , I.-F. , Chang , H.-Y. and James Shen , C.-K. ( 2006 ). Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition . Exp. Cell Res...
Includes: Supplementary data