... fine tune the induction of autophagy without complete abrogation. In this Review, we summarize the recent discoveries on the mechanism of regulation of ATG (autophagy related) gene expression at the level of transcription, post transcription and translation. Furthermore, we briefly discuss the role...

... transcriptional partners. However, the network of factors that controls SMAD2 chromatin binding and shapes its transcriptional programme over time is poorly characterised. Here, we combine ATAC-seq with computational footprinting to identify temporal changes in chromatin accessibility and transcription factor...

... to wild-type data, uncoupling Hi-C-measured long-range DNA contacts from transcriptional repression of the X chromosomes. Taken together, our results indicate that DPY-21 has a non-catalytic role in regulating the dynamics of condensin DC binding, which is important for transcription repression...

... signaling results in TAZ Ser89 phosphorylation and increased retention in the cytoplasm. Based on the repressive function of TAZ at the Ckm gene that we have documented here, we propose that TAZ represses myogenic transcription complexes under proliferative conditions, and activation of Hippo signaling...

... acetylation of histone H3K56. Acetylation at this site is important to allow access to chromatin after DNA damage, enhance histone turnover at transcriptionally active chromatin, and to promote nucleosome assembly during S phase ( Kaplan et al., 2008 ; Li et al., 2008 ; Topal et al., 2019 ; Wurtele et al...

... of toxic cadmium action in vivo . Curr. Genet. 64 , 177 - 181 . 10.1007/s00294-017-0748-x Thomas , B. J. and Rothstein , R. ( 1989 ). Elevated recombination rates in transcriptionally active DNA . Cell 56 , 619 - 630 . 10.1016/0092-8674(89)90584-9 Thorsen , M...

... early in infection remained unexplained. We thus assessed the amount of transcriptionally active nuclear vDNA. Cellular gene loci active in transcription have been visualized using RNA FISH targeting intron sequences ( Levesque and Raj, 2013 ; Shah et al., 2018 ), or by monitoring transcriptional...

..., suggests that MVI is present in a number of transcriptionally active areas in the nucleus. Furthermore, given the interaction of MVI with both the estrogen receptor ( Fili et al., 2017 ) and the androgen receptor ( Loikkanen et al., 2009 ), we speculate that MVI is required for the transcription...

... to the activity of class I/II HDACs localized near the nuclear envelope ( Finlan et al., 2008 ). Interestingly, gene loci targeted to the nuclear envelope can also be transcriptionally active ( Kumaran and Spector, 2008 ). As lamins are regulators of nuclear mechanotransduction ( Dahl et al., 2008 ; Hale et al...

... are transcriptionally upregulated during stress, and importantly, TFs can bind to both promoters and enhancers to regulate stress-induced gene transcription ( Maruyama et al., 2014 ; Vihervaara et al., 2017 ; Grossi et al., 2018 ; Lyu et al., 2018 ). However, the impact of enhancers on genome-wide and stress...

... of cellular pre-mRNA splicing takes place co-transcriptionally, but has also shown that the elongation and pausing rates of Pol II can influence alternative splicing decisions ( Herzel et al., 2017 ). Specifically, our data is consistent with the previous observation that slower rates of Pol II elongation...

... proteins at the transcriptionally active chromatin region, and HP1b may be recruited through forming heterodimers with HP1c at the region. Taken together, these data indicate that HP1b and HP1c may counteract HP1a function both in heterochromatin formation and in the active transcriptional regulation...

... and chromatin-remodeling factors that migrate along DNA. In terms of genome biology, the term compartment is narrowly defined: compartments are untethered, but self-interacting domains of transcriptionally active (open or A domains) or repressed (closed or B domains) chromatin states that may contain 5 to 50...

... is also regulated by Upf1 at the level of transcription. We first analyzed Arc mRNA and pre-mRNA levels in Upf1 knockdown and KO cells by qRT-PCR and found that these did not differ significantly ( Figs 1 C,D and 2 B–D), strongly suggesting that Arc mRNA is transcriptionally modulated. The Arc...

... pattern in sporozoites and ookinetes. To evaluate the expression pattern of Spooki 1.0, a parasite line named Spooki 1.0 mCherry was generated that expresses mCherry under the control of Spooki 1.0 in a transcriptionally silent region of chromosome 12 ( Fig. 2 A; Fig. S1 ). Live-cell imaging...

...Maximilien Courgeon; Dan Qing He; Hui Hua Liu; Kevin Legent; Jessica E. Treisman ABSTRACT Mammalian members of the ErbB family, including the epidermal growth factor receptor (EGFR), can regulate transcription, DNA replication and repair through nuclear entry of either the full-length proteins...

... fusion in the formation of efficient, bone-resorbing OCs ( Lees and Heersche, 1999 , 2000 ; Lees et al., 2001 ) underlines pre-OC fusion as a central control locus in OC-mediated bone loss. We assessed whether RANKL-mediated adseverin expression was regulated transcriptionally by conducting...

... occurs during the pre-MBT, we expected to observe core and CAK colocalization in transcriptionally active nuclei in pre-MBT embryos (i.e. at the interphase of NC8 and onwards). However, in addition to the nuclear localization of TFIIH core subunits during interphase, in this study, we noted some nuclear...

... signalling. Sck2 had the greatest effect on cell growth, and we also show that it significantly increases the cellular transcription rate. These findings indicate, for the first time, that global transcriptional control mediated through S6 kinase signalling is central to cellular growth control...

... with the cloverleaf structure of the EV71 RNA 5′UTR to inhibit viral RNA transcription, and binds to the internal ribosome entry site (IRES) of the EV71 5′UTR to attenuate viral RNA translation. Thus, EV71 stimulates SIRT1 production and activity, which in turn represses EV71 genome replication by inhibiting viral...