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Keywords: Traction force
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Journal Articles
Journal Articles
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Cell migration
J Cell Sci (2017) 130 (14): 2329–2343.
Published: 15 July 2017
... the front, while p21-activated kinase 2 (PAK2), a regulator of MLC kinase (MYLK), is mislocalized. Inhibition or depletion of MYLK restores FA distribution in β-PIX knockdown cells. Traction forces generated by β-PIX knockdown cells are increased relative to those in control cells, a result consistent...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (19): 3661–3674.
Published: 1 October 2016
... talin1. Replacement of talin2 Ser339 with Cys significantly decreased its binding to β1-integrin tails to a level comparable to that of talin1. Talin2 localizes at invadopodia and is indispensable for the generation of traction force and invadopodium-mediated matrix degradation. Ablation of talin2...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2015) 128 (7): 1316–1326.
Published: 1 April 2015
...-out force transmission. α5β1 and αvβ3 each mediate actin cytoskeletal remodeling in response to stiffening or cyclic stretching of the ECM. Likewise, α5β1 and αvβ3 support cellular traction forces of comparable magnitudes and similarly increase these forces in response to ECM stiffening. However...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (1): 155–165.
Published: 1 January 2012
..., their distribution determines the pattern of traction forces propelling the cell in a certain direction. In the present study, we quantitatively analyzed the spatial patterning of cell–substrate adhesion in migrating cells by mapping averaged focal adhesion growth dynamics to a standardized cell coordinate system...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4233–4240.
Published: 15 December 2011
...Andrew Rape; Wei-hui Guo; Yu-li Wang Traction forces increase after microtubule depolymerization; however, the signaling mechanisms underlying this, in particular the dependence upon myosin II, remain unclear. We investigated the mechanism of traction force increase after nocodazole-induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (3): 413–423.
Published: 1 February 2010
... irrespective of the nature of adhesive contacts. When NMII activity is inhibited during cell spreading by Rho kinase inhibition, blebbistatin, caldesmon overexpression or NMIIA RNAi, the symmetric traction forces are lost and cell spreading persists, causing cytoplasm fragmentation by membrane tension...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3581–3588.
Published: 1 November 2008
... subunits encoded by the Capn1 and Capn2 genes, respectively, and the small regulatory subunit encoded by Capn4 . We have examined the role of the calpain regulatory small subunit in traction force production and mechanosensing during cell migration. Capn4 -deficient or rescued cells were plated on flexible...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (20): 3285–3292.
Published: 15 October 2008
... transition that allows the cytoskeleton to shift through different physical forms, and not a specific biochemical mechanism. Interestingly, when applying minute forces to single adhesion sites and subsequently measuring cellular traction forces, one observes massive changes in cellular contractility...
Journal Articles
Journal Articles
J Cell Sci (2003) 116 (8): 1617–1625.
Published: 15 April 2003
... measurements show that a myosin-dependent viscoelastic force resists cell deformation. * Author for correspondence (e-mail: elson@biochem.wustl.edu ) 2 1 2003 © The Company of Biologists Limited 2003 2003 Myosin II Cell spreading Cell mechanics Traction force Contraction...
Journal Articles
J Cell Sci (2003) 116 (1): 51–60.
Published: 1 January 2003
...Kazuhiko S. K. Uchida; Toshiko Kitanishi-Yumura; Shigehiko Yumura Cells must exert force against the substrate to migrate. We examined the vectors (both the direction and the magnitude) of the traction force generated by Dictyostelium cells using an improved non-wrinkling silicone substrate. During...
Includes: Multimedia, Supplementary data