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Keywords: Tight junctions
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Journal Articles
J Cell Sci (2018) 131 (3): jcs208736.
Published: 5 February 2018
... remaining sufficiently plastic to allow events such as cytokinesis to take place is a key biological problem. In vertebrates, the remodelling and reinforcement of adherens junctions maintains epithelial integrity during cytokinesis. The involvement of tight junctions in cell division, however, has remained...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 243–259.
Published: 1 January 2017
.... Failure of these processes can result in serious developmental anomalies. Although tight junction assembly is crucial to epithelial polarization, the contribution of specific tight junction proteins to lumenogenesis is undefined. Here, we show that ZO-1 (also known as TJP1) is necessary for the formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (17): 3990–3999.
Published: 1 September 2013
...Imogen A. Elsum; Claire Martin; Patrick O. Humbert Summary The crucial role the Crumbs and Par polarity complexes play in tight junction integrity has long been established, however very few studies have investigated the role of the Scribble polarity module. Here, we use MCF10A cells, which fail...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3356–3368.
Published: 1 October 2011
... in polarised epithelial tissues, but its function in these tissues and the relationship with the disorder are unknown. Here we show colocalisation of POF1B with markers of both adherens and tight junctions in human jejunum. The tight junction localisation was maintained by the human POF1B stably expressed...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2803–2809.
Published: 15 August 2010
... form adherens junctions (AJs) but completely lack tight junctions (TJs) – fully activated SRF. By contrast, AGS gastric adenocarcinoma epithelial cells, which form TJs but are deficient in E-cadherin, and therefore also in AJs, failed to activate SRF. The introduction of wild-type E-cadherin in AGS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 985–994.
Published: 1 April 2009
...Senye Takahashi; Noriko Iwamoto; Hiroyuki Sasaki; Masato Ohashi; Yukako Oda; Shoichiro Tsukita; Mikio Furuse The structural continuity of tight junctions (TJs) is consistently maintained even when epithelial cells divide and move within the cellular sheet. This process is associated with dynamic...
Journal Articles
J Cell Sci (2008) 121 (6): 814–824.
Published: 15 March 2008
...Ernesto Sabath; Hideyuki Negoro; Sarah Beaudry; Manuel Paniagua; Susanne Angelow; Jagesh Shah; Nicholas Grammatikakis; Alan S. L. Yu; Bradley M. Denker The polarized functions of epithelia require an intact tight junction (TJ) to restrict paracellular movement and to separate membrane proteins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (3): 298–305.
Published: 1 February 2008
...Christina M. Van Itallie; Jennifer Holmes; Arlene Bridges; Jody L. Gookin; Maria R. Coccaro; William Proctor; Oscar R. Colegio; James M. Anderson Epithelial tight junctions contain size- and charge-selective pores that control the paracellular movement of charged and noncharged solutes. Claudins...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2838–2850.
Published: 15 August 2007
.... Here, we report on shroom2, a submembranous PDZ domain-containing protein that is associated with the tight junctions in multiple embryonic and adult epithelia. Shroom2 directly interacts with the C-terminal MyTH4-FERM domain of myosin VIIa and with F-actin. In addition, a shroom2 fragment containing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (14): 2352–2365.
Published: 15 July 2007
...Takako Ooshio; Naoyuki Fujita; Akio Yamada; Tatsuhiro Sato; Yuichi Kitagawa; Ryoko Okamoto; Shinsuke Nakata; Ayaka Miki; Kenji Irie; Yoshimi Takai Par-3 is a cell-polarity protein that regulates the formation of tight junctions (TJs) in epithelial cells, where claudin is a major cell-cell adhesion...
Journal Articles
J Cell Sci (2005) 118 (17): 4049–4057.
Published: 1 September 2005
... lines of Caco2 to clarify its role in epithelial morphogenesis. In PATJ knockdown cells, Pals1 (a Stardust homologue) is no longer associated with tight junctions whereas Crumbs3 (Crb3) is accumulated into a compartment spatially close to the apical membrane and related to early endosomes. Furthermore...
Journal Articles
J Cell Sci (2005) 118 (7): 1427–1436.
Published: 1 April 2005
...-forming proteins of the tight junction, are palmitoylated and whether this modification has functional implications for the tight-junction barrier. Claudin-14, like other members of the claudin family, contains membrane-proximal cysteines following both the second and the fourth transmembrane domains...
Journal Articles
J Cell Sci (2004) 117 (15): 3307–3318.
Published: 1 July 2004
...Christoph Rahner; Masayuki Fukuhara; Shaomin Peng; Shota Kojima; Lawrence J. Rizzolo A culture model has been established to study the gradual development of tight junctions during the embryogenesis of the chick retinal pigment epithelium. This study asks how closely the culture model reflects...
Journal Articles
J Cell Sci (2004) 117 (10): 2097–2107.
Published: 15 April 2004
... junctions. The dramatic morphological changes observed in apoptotic epithelial cells were ascribed at least in part to the specific fragmentation of components of adherens junctions and desmosomes. Little, however, is known about tight junctions during apoptosis. We have found that after induction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (5): 783–798.
Published: 15 February 2004
...Ching-hang Wong; Dolores D. Mruk; Wing-yee Lui; C. Yan Cheng An in vivo model was used to investigate the regulation of tight junction (TJ) dynamics in the testis when adult rats were treated with CdCl 2 . It was shown that the CdCl 2 -induced disruption of the blood-testis barrier (BTB) associated...
Journal Articles
J Cell Sci (2004) 117 (1): 19–29.
Published: 1 January 2004
... enriched at tight junctions. The recent identification of extracellular ligands and intracellular binding proteins for JAMs suggests two functions for JAMs. JAMs associate through their extracellular domains with the leukocyte β2 integrins LFA-1 and Mac-1 as well as with the β1 integrin α4β1. All three...
Journal Articles
J Cell Sci (2003) 116 (7): 1187–1197.
Published: 1 April 2003
... of patients with colorectal carcinoma. Progastrin induced the dissociation of both tight junction (TJ) and adherens junction (AJ) complexes in IMGE-5 cells. In progastrin-secreting DLD-1 human colorectal carcinoma cells, expression of an antisense gastrin construct restored membrane localisation of zonula...
Journal Articles
J Cell Sci (2003) 116 (7): 1279–1289.
Published: 1 April 2003
... and immunoelectron microscopy revealed that MAGI-3 is concentrated in specific sites at the plasma membrane and in the nucleus. In epithelial cells, MAGI-3 was localized with ZO-1 and cingulin at tight junctions, whereas in primary cultured astrocytes it was found in E-cadherin-based cell-cell contacts and in focal...
Journal Articles
J Cell Sci (2003) 116 (1): 17–27.
Published: 1 January 2003
... junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis. * Author for correspondence (e-mail: ytakai...
Journal Articles
J Cell Sci (1993) 1993 (Supplement_17): 127–132.
Published: 1 December 1993
...M. Cereijido; L. González-Mariscal; R. G. Contreras; J. M. Gallardo; R. García-Villegas; J. Valdés SUMMARY MDCK (epithelial cells from the dog kidney) plated at confluence, establish tight junctions in 12–15 hours through a process that requires protein synthesis, formation of a ring of actin...