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Keywords: Tiam1
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Journal Articles
Journal Articles
J Cell Sci (2021) 134 (7): jcs252502.
Published: 13 April 2021
... duplication. Here, we show that the Rac1 guanine nucleotide exchange factor (GEF) Tiam1 localises to centrosomes during S-phase, where it is required for the maintenance of normal centriole number. Depletion of Tiam1 leads to an increase in centrosomal PLK4 and centriole overduplication, whereas...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2007) 120 (2): 279–288.
Published: 15 January 2007
... by fibrillar amyloid-beta peptide (Aβ) is associated with increased activity of Rac1/Cdc42 Rho GTPases. Rac1 upregulation involves the participation of Tiam1, a Rac guanine-nucleotide exchange factor, where Aβ exposure leads to Tiam1 activation by a Ca 2+ -dependent mechanism. These results point to Rho...
Includes: Supplementary data
Journal Articles