...Lisa te Molder; Juri Juksar; Rolf Harkes; Wei Wang; Maaike Kreft; Arnoud Sonnenberg ABSTRACT Tetraspanin CD151 has been suggested to regulate cell adhesion through its association with laminin-binding integrins α3β1 and α6β4; however, its precise function in keratinocyte adhesion remains elusive...

...Rafal Sadej; Xiaohong Lu; Lukasz Turczyk; Vera Novitskaya; Andrea F. Lopez-Clavijo; Radzisław Kordek; Piotr Potemski; Michael J. O. Wakelam; Hanna Romanska-Knight; Fedor Berditchevski ABSTRACT Expression of the tetraspanin CD151 is frequently upregulated in epithelial malignancies and correlates...

... remain elusive. Here, we show that CLEC-2-dependent DC migration is controlled by tetraspanin CD37, a membrane-organizing protein. We identified a specific interaction between CLEC-2 and CD37, and myeloid cells lacking CD37 ( Cd37 −/− ) expressed reduced surface CLEC-2. CLEC-2-expressing Cd37 −/− DCs...

... on immunolocalization of Mesh identified a tetraspanin family protein, Tsp2A, as a newly discovered protein involved in sSJ formation in Drosophila . Tsp2A specifically localizes at sSJs in the midgut and Malpighian tubules. Compromised Tsp2A expression caused by RNAi or the CRISPR/Cas9 system was associated...

... ) induces inhibition of neurite outgrowth, cell spreading, adhesion and migration through multi-subunit receptor complexes. Here, we identified the four-transmembrane-spanning protein tetraspanin-3 (TSPAN3) as a new modulatory co-receptor for the Nogo-A inhibitory domain Nogo-A-Δ20. Single-molecule tracking...

...Stéphanie Charrin; Stéphanie Jouannet; Claude Boucheix; Eric Rubinstein ABSTRACT Tetraspanins are a family of proteins with four transmembrane domains that play a role in many aspects of cell biology and physiology; they are also used by several pathogens for infection and regulate cancer...

... that the intrinsically disordered cytoplasmic C-terminus of the photoreceptor tetraspanin peripherin-2/rds (P/rds) can directly generate membrane curvature. A P/rds C-terminal domain and a peptide mimetic of an amphipathic helix contained within it each generated curvature in liposomes with a composition similar...

... of tetraspanin function relevant to metastasis. * Author for correspondence ( gammi001@umn.edu ) 14 01 2013 © 2013. Published by The Company of Biologists Ltd 2013 Epithelial-to-mesenchymal transition Neural crest Tetraspanin Cadherin Epithelial-to-mesenchymal transition (EMT...

... of Korea to J.W.L. References Berditchevski   F. ( 2001 ). Complexes of tetraspanins with integrins: more than meets the eye.   J. Cell Sci.   114 , 4143 – 4151 . Bolós   V. , Gasent   J. M. , López–Tarruella   S. , Grande   E. ( 2010 ). The dual kinase complex FAK-Src...

...Xiuwei H. Yang; Rossen Mirchev; Xinyu Deng; Patrick Yacono; Helen L. Yang; David E. Golan; Martin E. Hemler Laminin-binding integrins (α3β1, α6β1, α6β4, α7β1) are almost always expressed together with tetraspanin CD151. In every coexpressing cell analyzed to date, CD151 makes a fundamental...

...Tineke van den Hoorn; Petra Paul; Lennert Janssen; Hans Janssen; Jacques Neefjes Late endosomal multivesicular bodies (MVBs) are complicated organelles with various subdomains located at the limiting membrane and the internal vesicles (ILVs). ILVs accumulate tetraspanins such as CD63 and CD82...

...Hong-Xing Wang; Tatiana V. Kolesnikova; Carilee Denison; Steven P. Gygi; Martin E. Hemler Tetraspanin protein CD9 supports sperm–egg fusion, and regulates cell adhesion, motility, metastasis, proliferation and signaling. The large extracellular loop and transmembrane domains of CD9 engage...

... depletion reduces the cell surface amount of CD82, a tetraspanin known to control EGFR localization in microdomains. We further show that TI-VAMP is required for secretion from the Golgi apparatus to the cell surface, and that TI-VAMP-positive vesicles transport CD82. Quantum dots video-microscopy indicates...

...Jessica L. Johnson; Nicole Winterwood; Kris A. DeMali; Christopher S. Stipp Tetraspanins regulate integrin-dependent tumor cell interactions with the extracellular matrix. Here we show that tetraspanin CD151, which plays critical roles in regulating the adhesion and motility of individual tumor...

...Isabella Imhof; Warren J. Gasper; Rik Derynck Ligand presentation is a major determinant of receptor activation. The epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, is activated by growth factors of the transforming growth factor α (TGFα) family. The tetraspanin CD9 interacts...

... of transmembrane regions is sufficient for directing L6-Ag to LEO. On the plasma membrane, L6-Ag is associated with tetraspanin-enriched microdomains (TERM). All three predicted cytoplasmic regions of L6-Ag are crucial for the effective recruitment of the protein to TERM. Recruitment to TERM correlated...

... cells require αvβ5 integrin receptors for particle binding that triggers engulfment. Here, we show that tetraspanins CD81 and CD9 reside in a complex specifically with αvβ5 integrin but not the engulfment receptors Mer tyrosine kinase and CD36 at the apical, phagocytic surface of RPE cells. Function...

...Hiroki Moribe; John Yochem; Hiromi Yamada; Yo Tabuse; Toyoshi Fujimoto; Eisuke Mekada Epidermal integrity is essential for animal development and survival. Here, we demonstrate that TSP-15, a member of the tetraspanin protein family, is required for epithelial membrane integrity in Caenorhabditis...

... dynamics. Here, we have studied the relationships between tetraspanins, cytoskeleton and raft microdomains, and their relevance in T-cell signaling. Localization studies and density-gradient flotation experiments indicate that part of tetraspanins localizes in raft microdomains linked to the actin...

...Yoko Murayama; Jun-ichiro Miyagawa; Kenji Oritani; Hitoshi Yoshida; Katsumi Yamamoto; Osamu Kishida; Tamana Miyazaki; Shusaku Tsutsui; Tatsuya Kiyohara; Yoshiji Miyazaki; Shigeki Higashiyama; Yuji Matsuzawa; Yasuhisa Shinomura CD9, a member of the tetraspanin family, has been shown to be involved...