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Keywords: Tau
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2024) 137 (1): jcs261244.
Published: 10 January 2024
..., how netrin-1 (NTN1) regulates MT dynamics in axon turning remains a major unanswered question. Here, we show that the coupling of netrin-1 receptor DCC with tau (MAPT)-regulated MTs is involved in netrin-1-promoted axon attraction. Tau directly interacts with DCC and partially overlaps with DCC...
Includes: Supplementary data
Journal Articles
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Mitochondria
J Cell Sci (2023) 136 (13): jcs260993.
Published: 7 July 2023
... explores the prospect of import machinery perturbation as a cause of neurodegeneration instigated by the accumulation of aggregating proteins linked to disease. We found that the aggregation-prone Tau variant (Tau P301L ) reduces the levels of components of the import machinery of the outer (TOM20, encoded...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs248815.
Published: 8 January 2021
... independently of its effects on non-muscle myosin II. UNC-45A Microtubules Microtubule lattice Microtubule-destabilizing proteins Tau UNC-45, a highly conserved member of the UCS (UNC-45/CRO1/She4p) family, was discovered in the early 1970s, when mutations in its encoding gene caused...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (14): jcs229054.
Published: 15 July 2019
...Yohan Kim; Guanghao Liu; Chad J. Leugers; Joseph D. Mueller; Meghan B. Francis; Marco M. Hefti; Julie A. Schneider; Gloria Lee ABSTRACT Microtubule-associated protein tau, an integral component of neurofibrillary tangles, interacts with a variety of signaling molecules. Previously, our laboratory...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (3): jcs211987.
Published: 8 February 2018
... of the Golgi unexpectedly demonstrated that the intact Golgi ribbon is essential for regulating the mTOR pathway and autophagy. Golgi ribbon Autophagy Golgins mTOR LC3 Tau Golgi fragmentation Neurodegeneration In contrast to protists, plants and invertebrates, vertebrates have evolved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 2079–2091.
Published: 1 May 2013
...Yee Lian Chew; Xiaochen Fan; Jürgen Götz; Hannah R. Nicholas Summary Protein with tau-like repeats (PTL-1) is the sole Caenorhabditis elegans homolog of tau and MAP2, which are members of the mammalian family of microtubule-associated proteins (MAPs). In mammalian neurons, tau and MAP2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1278–1286.
Published: 1 March 2013
... disease (AD). We now report that this ectopic cell cycle re-entry (CCR) requires soluble amyloid-β (Aβ) and tau, the respective building blocks of the insoluble plaques and tangles that accumulate in AD brain. Exposure of cultured wild type (WT) neurons to Aβ oligomers caused CCR and activation of the non...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (5): 748–757.
Published: 1 March 2007
...Vandana M. Sharma; Joel M. Litersky; Kiran Bhaskar; Gloria Lee The microtubule-associated protein tau interacts with the SH3 domain of non-receptor Src family protein tyrosine kinases. A potential consequence of the SH3 interaction is the upregulation of tyrosine kinase activity. Here we...
Journal Articles
J Cell Sci (2005) 118 (20): 4645–4654.
Published: 15 October 2005
...Michelle A. Utton; Wendy J. Noble; Josephine E. Hill; Brian H. Anderton; Diane P. Hanger Tau and α-synuclein are both proteins implicated in the pathology of neurodegenerative disease. Here we have investigated the mechanisms of axonal transport of tau and α-synuclein, because failure of axonal...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (25): 6129–6141.
Published: 1 December 2004
...Andrey Samsonov; Jiang-Zhou Yu; Mark Rasenick; Sergey V. Popov Tau is a major microtubule-associated protein which induces bundling and stabilization of axonal microtubules (MTs). To investigate the interaction of tau with MTs in living cells, we expressed GFP-tau fusion protein in cultured Xenopus...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2004) 117 (24): 5721–5729.
Published: 15 November 2004
...Gail V. W. Johnson; William H. Stoothoff Tau is a group of neuronal microtubule-associated proteins that are formed by alternative mRNA splicing and accumulate in neurofibrillary tangles in Alzheimer's disease (AD) brain. Tau plays a key role in regulating microtubule dynamics, axonal transport...
Journal Articles
Journal Articles
J Cell Sci (2001) 114 (6): 1179–1187.
Published: 15 March 2001
...Hana N. Dawson; Adriana Ferreira; Michele V. Eyster; Nupur Ghoshal; Lester I. Binder; Michael P. Vitek ABSTRACT Conflicting evidence supports a role for tau as an essential neuronal cytoskeletal protein or as a redundant protein whose function can be fulfilled by other microtubule-associated...
Journal Articles
J Cell Sci (2000) 113 (15): 2797–2809.
Published: 1 August 2000
... study, we determined the location of the dephosphorylated form of the microtubule-associated protein tau (dtau) within the growth cones of newly forming axons and examined whether this localization was influenced by the actin cytoskeleton. Following elongation of the initial axon at 2-3 days in vitro...
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (1998) 111 (21): 3167–3177.
Published: 1 November 1998
...Gloria Lee; S. Todd Newman; David L. Gard; Hamid Band; Govindaswamy Panchamoorthy ABSTRACT Tau and other microtubule-associated proteins promote the assembly and stabilization of neuronal microtubules. While each microtubule-associated protein has distinct properties, their in vivo roles remain...
Journal Articles
J Cell Sci (1998) 111 (10): 1419–1432.
Published: 15 May 1998
...Marie-Thérèse Vanier; Pascal Neuville; Liliane Michalik; Jean-François Launay ABSTRACT Tau is a neuron-specific microtubule-associated protein (MAP) that is required for the development and maintaining neuronal cell polarity. Tau is encoded by a single gene, while its transcript undergoes a complex...
Journal Articles