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Keywords: TFAM
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Journal Articles

YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas

In collection:
Mitochondria
Shruti Patrick, Pruthvi Gowda, Kirti Lathoria, Vaishali Suri, Ellora Sen
Journal: Journal of Cell Science
J Cell Sci (2021) 134 (22): jcs259188.
DOI: https://doi.org/10.1242/jcs.259188
Published: 24 November 2021
... protein 1 (YAP1) is an important regulator of tumor progression, its role in glioma expressing IDH1 with an R132H mutation was investigated. Diminished nuclear levels of YAP1 in IDH1 mutant glioma tissues and cell lines were accompanied by decreased levels of mitochondrial transcription factor A (TFAM...
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Includes: Supplementary data
Journal Articles

Mitochondrial DNA replication during differentiation of murine embryonic stem cells

Joao M. Facucho-Oliveira, Jon Alderson, Emma C. Spikings, Stuart Egginton, Justin C. St. John
Journal: Journal of Cell Science
J Cell Sci (2007) 120 (22): 4025–4034.
DOI: https://doi.org/10.1242/jcs.016972
Published: 15 November 2007
... by the mitochondrial genome (mtDNA). MtDNA replication is regulated by the nuclear-encoded mitochondrial transcription factor A (TFAM) and the mitochondrial-specific DNA polymerase gamma, which consists of a catalytic (POLG) and an accessory (POLG2) subunit. Differentiation of pluripotent embryonic stem cells (ESCs...
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Includes: Supplementary data