... stomatitis virus glycoprotein (VSVG) was largely unaffected. Knockdown of syntaxin 6 (STX6) also blocked the Golgi exit of Met. Depletion of either ASM or STX6 led to aberrant trafficking of Met to lysosomes, promoting its degradation. Our studies reveal that ASM and ceramides, together with STX6...

... back into the IRC, whereas the Q-SNARE syntaxin 6 is required for this process. * Author for correspondence (e-mail: jpessin@aecom.yu.edu ) 19 1 2008 © The Company of Biologists Limited 2008 2008 IRAP Insulin AS160 Syntaxin 6 GGA GLUT4 The insulin-responsive...

... cores. Vesicles containing non-secreted, internalized prolactin did not colocalize with DiI-LDL that had been chased into lysosomes but did transiently colocalize with internalized transferrin. The recycling vesicles also trafficked through a syntaxin 6-positive compartment but not the TGN38-positive...