...Oisun Jung; DeannaLee M. Beauvais; Kristin M. Adams; Alan C. Rapraeger ABSTRACT When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2...

... and rheumatoid arthritis. The heparan sulphate proteoglycan syndecan-2 is expressed on mesenchymal cells in the vasculature and, like the other members of its family, can be shed from the cell surface resulting in the release of its extracellular core protein. The purpose of this study was to establish whether...

... cell–cell junctions rich in zona occludens (ZO)-1, β-catenin and heparan sulfate, required syndecan-4 but not fibronectin or protein kinase C α (PKCα) to assemble extracellular matrix (fibrillin microfibrils and perlecan). In contrast, RPE cells that strongly expressed mesenchymal smooth muscle α-actin...

... of syntenin with syndecan heparan sulphate proteoglycans, which act as co-receptors for adhesion molecules and growth factors. Furthermore, we show that the interaction of syntenin with phosphatidylinositol 4,5-bisphosphate (PIP2) and with the small GTPase ADP-ribosylation factor 6 (Arf6), which regulate...

... Alexander C. M. , Reichsman F. , Hinkes M. T. , Lincecum J. , Becker K. A. , Cumberledge S. , Bernfield M. ( 2000 ). Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice . Nat. Genet. 25 , 329 - 332 . Bafico A. , Liu G. , Yaniv...

...DeannaLee M. Beauvais; Alan C. Rapraeger Syndecan-1 (Sdc1) engages and activates the αvβ3 (and/or αvβ5) integrin when clustered in human carcinoma and endothelial cells. Although the engagement is extracellular, the activation mechanism is cytoplasmic. This talin-dependent, inside-out signaling...

.... Although most of the enzymes involved in the biosynthesis and modification of heparan sulfate have been characterized in C. elegans , little is known regarding the core proteins to which these GAGs covalently bind in proteoglycans. A single syndecan homologue ( sdn-1 ) has been identified in the C. elegans...