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Keywords: Syndecan
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Journal Articles
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Cell Migration
J Cell Sci (2019) 132 (20): jcs232645.
Published: 28 October 2019
...Oisun Jung; DeannaLee M. Beauvais; Kristin M. Adams; Alan C. Rapraeger ABSTRACT When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4788–4799.
Published: 1 November 2014
... and rheumatoid arthritis. The heparan sulphate proteoglycan syndecan-2 is expressed on mesenchymal cells in the vasculature and, like the other members of its family, can be shed from the cell surface resulting in the release of its extracellular core protein. The purpose of this study was to establish whether...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (1): 158–171.
Published: 1 January 2014
... cell–cell junctions rich in zona occludens (ZO)-1, β-catenin and heparan sulfate, required syndecan-4 but not fibronectin or protein kinase C α (PKCα) to assemble extracellular matrix (fibrillin microfibrils and perlecan). In contrast, RPE cells that strongly expressed mesenchymal smooth muscle α-actin...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (2): 449–460.
Published: 15 January 2012
... Alexander C. M. , Reichsman F. , Hinkes M. T. , Lincecum J. , Becker K. A. , Cumberledge S. , Bernfield M. ( 2000 ). Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice . Nat. Genet. 25 , 329 - 332 . Bafico A. , Liu G. , Yaniv...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (21): 3796–3807.
Published: 1 November 2010
...DeannaLee M. Beauvais; Alan C. Rapraeger Syndecan-1 (Sdc1) engages and activates the αvβ3 (and/or αvβ5) integrin when clustered in human carcinoma and endothelial cells. Although the engagement is extracellular, the activation mechanism is cytoplasmic. This talin-dependent, inside-out signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2000) 113 (3): 493–506.
Published: 1 February 2000
...Carmen M. Klass; John R. Couchman; Anne Woods ABSTRACT Extracellular matrix (ECM) deposition and organization is maintained by transmembrane signaling and integrins play major roles. We now show that a second transmembrane component, syndecan-2 heparan sulfate proteoglycan, is pivotal in matrix...
Journal Articles
J Cell Sci (1999) 112 (20): 3415–3420.
Published: 15 October 1999
...John R. Couchman; Anne Woods ABSTRACT It is now becoming clear that additional transmembrane components can modify integrin-mediated adhesion. Syndecan-4 is a transmembrane heparan sulfate proteoglycan whose external glycosaminoglycan chains can bind extracellular matrix ligands and whose core...
Journal Articles
J Cell Sci (1999) 112 (20): 3433–3441.
Published: 15 October 1999
...Frank Echtermeyer; Peter C. Baciu; Stefania Saoncella; Yimin Ge; Paul F. Goetinck ABSTRACT The formation of focal adhesions and actin stress fibers on fibronectin is dependent on signaling through β1 integrins and the heparan sulfate proteoglycan syndecan-4, and we have analyzed the requirement...
Journal Articles
J Cell Sci (1999) 112 (20): 3421–3431.
Published: 15 October 1999
...Robert L. Longley; Anne Woods; Allison Fleetwood; Graham J. Cowling; John T. Gallagher; John R. Couchman ABSTRACT Syndecan-4 is a widely expressed transmembrane heparan sulfate proteoglycan which localizes to focal adhesions. Previous studies showed that the syndecan-4 cytoplasmic domain can...