...Stephen R. Wellard; Karen Schindler; Philip W. Jordan ABSTRACT Precise control of chromosome dynamics during meiosis is critical for fertility. A gametocyte undergoing meiosis coordinates formation of the synaptonemal complex (SC) to promote efficient homologous chromosome recombination. Subsequent...

... Synaptonemal complex Recombination Accurate chromosome inheritance from the diploid parental cell nucleus into haploid gametes depends on the intimate juxtaposition and recombination of paternal and maternal homologous chromosomes (see Glossary ) during meiosis. As recombination through crossovers...

... males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by super-resolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC...

...Abrahan Hernández-Hernández; Sergej Masich; Tomoyuki Fukuda; Anna Kouznetsova; Sara Sandin; Bertil Daneholt; Christer Höög ABSTRACT The synaptonemal complex transiently stabilizes pairing interactions between homologous chromosomes during meiosis. Assembly of the synaptonemal complex is mediated...

... formation requires the prior synapsis of homologous chromosome axes, which is mediated by the synaptonemal complex, a tripartite proteinaceous structure specific to prophase I of meiosis. Yemanuclein (Yem) is a maternal factor that is crucial for sexual reproduction. It is required in the zygote...

... at the central region of the synaptonemal complex from zygotene until diplotene. During late diplotene both proteins load to the chromocenters, where they colocalize with DNA Topoisomerase IIα, and then accumulate at the inner domain of the centromeres during the first and second meiotic divisions. Interestingly...

...Philip W. Jordan; Jesse Karppinen; Mary A. Handel Summary During meiosis, accurate coordination of the completion of homologous recombination and synaptonemal complex (SC) disassembly during the prophase to metaphase I (G2/MI) transition is essential to avoid aneuploid gametes and infertility...

...., Jessberger, R., Revenkova, E. and Heyting, C. ( 2003 ). Meiotic cohesion REC8 marks the axial elements of rat synaptonemal complexes before cohesins SMC1 and SMC3. J. Cell Biol. 160 , 657 -670. Ghyselinck, N. B., Vernet, N., Dennefeld, C., Giese, N., Nau, H., Chambon, P., Viville, S. and Mark, M...

...Geert Hamer; Hong Wang; Ewelina Bolcun-Filas; Howard J. Cooke; Ricardo Benavente; Christer Höög The synaptonemal complex is an elaborate meiosis-specific supramolecular protein assembly that promotes chromosome synapsis and meiotic recombination. We inactivated the meiosis-specific gene Tex12...

... ; Prieto et al., 2001 ; Revenkova and Jessberger, 2005 ). * Author for correspondence (e-mail: sharon.e.bickel@dartmouth.edu ) 3 7 2007 © The Company of Biologists Limited 2007 2007 Meiosis Cohesin Synaptonemal complex Recombination Accurate segregation...

...) by the acquisition of RPA, BLM, MSH4 and topoisomerases that function in repair and Holliday junction resolution. At the leptotene-zygotene transition, TNs orient to positions between the aligned cores where they initiate structural interhomolog contacts prior to synaptonemal complex (SC) formation, possibly future...

...Geert Hamer; Katarina Gell; Anna Kouznetsova; Ivana Novak; Ricardo Benavente; Christer Höög During the first meiotic prophase, alignment and synapsis of the homologous chromosomes are mediated by the synaptonemal complex. Incorrect assembly of this complex results in cell death, impaired meiotic...

... at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination. Curr. Biol. 14 , 585 -592. Dietrich, A. J., van Marle, J., Heyting, C. and Vink, A. C. ( 1992 ). Ultrastructural evidence for a triple structure of the lateral element of the synaptonemal complex. J. Struct. Biol...

...Yael Costa; Robert Speed; Rupert Öllinger; Manfred Alsheimer; Colin A. Semple; Philippe Gautier; Klio Maratou; Ivana Novak; Christer Höög; Ricardo Benavente; Howard J. Cooke Completion of meiosis in mammals depends on the formation of the synaptonemal complex, a tripartite structure...

.... Curr. Biol. 14 , 585 -592. Dobson, M. J., Pearlman, R. E., Karaiskakis, A., Spyropoulos, B. and Moens, P. B. ( 1994 ). Synaptonemal complex proteins: occurrence, epitope mapping and chromosome disjunction. J. Cell Sci. 107 , 2749 -2760. Eijpe, M., Heyting, C., Gross, B. and Jessberger...

...Janet K. Jang; Dalia E. Sherizen; Rajal Bhagat; Elizabeth A. Manheim; Kim S. McKim The relationship between synaptonemal complex formation (synapsis) and double-strand break formation (recombination initiation) differs between organisms. Although double-strand break creation is required for normal...

... it is no longer associated with the chromosomes. Immunogold labelling in conjunction with electron microscopy established that Asy1 localizes to regions of chromatin that associate with the axial/lateral elements of meiotic chromosomes rather than being a component of the synaptonemal complex itself. These data...

... trans-acting factor or factors. Since components of the synaptonemal complex are thought to play a role in centromere cohesion and kinetochore orientation, we evaluated the behavior of the X chromosome at prophase to determine if this factor influenced the propensity of the chromosome for self-synapsis...

... in establishing the presynaptic alignment of the homologous sites within the inverted regions and hence to achieve a high rate of inversion loop formation. Thickenings of the axial/lateral elements are not distributed equally along the synaptonemal complex. They are underrepresented in unpaired axes...