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Keywords: Stress granule
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Journal Articles
J Cell Sci (2022) 135 (4): jcs259194.
Published: 24 February 2022
... responses result in the rapid inhibition of translation and condensation of stalled mRNAs with RNA-binding proteins and signalling components into cytoplasmic biocondensates called stress granules (SGs). Increasing evidence suggests that SGs contribute to antiviral defence, and thus viruses need to evade...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs248310.
Published: 28 October 2020
...) into stress granules (SGs). Studies into mechanisms of SG formation and functions are complicated because various types of stress cause formation of SGs with different properties and composition. In this work, we focused on the mechanism of SG formation triggered by UV damage. We demonstrate that UV-induced...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs243451.
Published: 18 May 2020
...Kasun Buddika; Ishara S. Ariyapala; Mary A. Hazuga; Derek Riffert; Nicholas S. Sokol ABSTRACT Stressed cells downregulate translation initiation and assemble membrane-less foci termed stress granules (SGs). Although SGs have been extensively characterized in cultured cells, the existence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs234807.
Published: 18 October 2019
...Ruiqi Wang; Hefei Zhang; Jiulin Du; Jin Xu ABSTRACT Although the regulation of stress granules has become an intensely studied topic, current investigations of stress granule assembly, disassembly and dynamics are mainly performed in cultured cells. Here, we report the establishment of a stress...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs229252.
Published: 17 June 2019
...Richa Das; Lukas Schwintzer; Stanislav Vinopal; Eva Aguado Roca; Marc Sylvester; Ana-Maria Oprisoreanu; Susanne Schoch; Frank Bradke; Meike Broemer ABSTRACT Mechanisms that regulate the formation of membrane-less cellular organelles, such as neuronal RNA granules and stress granules, have gained...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (19): jcs220244.
Published: 5 October 2018
...Lucas C. Reineke; Shebna A. Cheema; Julien Dubrulle; Joel R. Neilson ABSTRACT Stress granules (SGs) assemble under stress-induced conditions that inhibit protein synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins or inactivation of mTORC1. Classically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (8): jcs210856.
Published: 12 April 2018
...Xuan Xie; Shunsuke Matsumoto; Akinori Endo; Toshiaki Fukushima; Hiroyuki Kawahara; Yasushi Saeki; Masayuki Komada ABSTRACT Stress granules are transient cytoplasmic foci induced by various stresses that contain translation-stalled mRNAs and RNA-binding proteins. They are proposed to modulate mRNA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs209114.
Published: 9 January 2018
... that CbHog1-Venus formed intracellular dot structures after high-temperature stress in a reversible manner. Microscopic observation revealed that CbHog1-mCherry colocalized with CbPab1-Venus, a marker protein of stress granules. Hog1 homologs in Pichia pastoris and Schizosaccharomyces pombe also exhibited...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4210–4219.
Published: 15 November 2015
... of biochemical fractionation experiments. We also show that human (HeLa) cells localize oxidized RNA to cytoplasmic foci that are distinct from stress granules, processing bodies and mitochondria. Our results suggest that the compartmentalization of oxidized RNA management is a general phenomenon and therefore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1542–1554.
Published: 15 April 2015
...Luciana Luchelli; María Gabriela Thomas; Graciela L. Boccaccio Repression of mRNA translation is linked to the formation of specific cytosolic foci such as stress granules and processing bodies, which store or degrade mRNAs. In neurons, synaptic activity regulates translation at the post‐synapse...
Journal Articles
J Cell Sci (2014) 127 (11): 2471–2482.
Published: 1 June 2014
...Peifen Zhang; Yuye Li; Jun Xia; Junfang He; Jieying Pu; Jiong Xie; Siyu Wu; Lianqiang Feng; Xi Huang; Ping Zhang ABSTRACT The formation of cytoplasmic stress granules and the innate immune response are two distinct cellular stress responses. Our study investigated the involvement of four innate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3973–3982.
Published: 1 November 2009
...Mariela Loschi; Claudia C. Leishman; Neda Berardone; Graciela L. Boccaccio Stress granules (SGs) and P-bodies (PBs) are related cytoplasmic structures harboring silenced mRNAs. SGs assemble transiently upon cellular stress, whereas PBs are constitutive and are further induced by stress. Both foci...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2774–2784.
Published: 15 August 2007
... function in this compartment. In the present study, we show that MLN51 is recruited into cytoplasmic aggregates known as stress granules (SGs) together with the SG-resident proteins, fragile X mental retardation protein (FMRP), poly(A) binding protein (PABP) and poly(A) + RNA. MLN51 specifically associates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (17): 3557–3570.
Published: 1 September 2003
... compartmentalization of HSF1 into nuclear stress granules has been suggested to be an important control step in the regulation of stress response and cellular homeostasis in human cells. In this study, we demonstrate that the less-well characterized HSF2 interacts physically with HSF1 and is a novel stress-responsive...