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Keywords: Senescence
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Journal Articles
J Cell Sci (2022) 135 (15): jcs259738.
Published: 2 August 2022
...Chenghao Ren; Jie Jin; Chenchao Li; Jianwei Xiang; Yaosen Wu; Yifei Zhou; Liaojun Sun; Xiaolei Zhang; Naifeng Tian ABSTRACT Intervertebral disc degeneration (IVDD) is a complex process involving many factors, among which excessive senescence of nucleus pulposus cells is considered to be the main...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259513.
Published: 25 May 2022
... humans and mice have shown that TPPII deficiency is linked to cellular immune-senescence, lifespan regulation and the aging process. However, the mechanism of how TPPII participates in these processes is less clear. In this study, we established a chemical probe-based assay and found that although...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259114.
Published: 28 April 2022
...Gérald Lossaint; Anđela Horvat; Véronique Gire; Katarina Bačević; Karim Mrouj; Fabienne Charrier-Savournin; Virginie Georget; Daniel Fisher; Vjekoslav Dulić ABSTRACT Senescence is an irreversible withdrawal from cell proliferation that can be initiated after DNA damage-induced cell cycle arrest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs252080.
Published: 22 February 2021
...Sven E. Niklander; Hannah L. Crane; Lav Darda; Daniel W. Lambert; Keith D. Hunter ABSTRACT There is compelling evidence that senescent cells, through the senescence-associated secretory phenotype (SASP), can promote malignant transformation and invasion. Interleukin-1 (IL-1) is a key mediator...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (2): jcs232470.
Published: 23 January 2020
...Deepraj Ghosh; Carolina Mejia Pena; Nhat Quach; Botai Xuan; Amy H. Lee; Michelle R. Dawson ABSTRACT Mesenchymal stem cells (MSCs) are essential for the regenerative process; however, biological aging and environmental stress can induce senescence – an irreversible state of growth arrest...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (13): jcs229385.
Published: 1 July 2019
.... Following this mitotic slippage, cells with decreased DNA-PKcs underwent accelerated cellular senescence. We identified downregulation of ataxia-telangiectasia mutated kinase (ATM) as the critical role of DNA-PKcs in recovery from DNA damage, insofar as targeting ATM restored γH2AX foci resolution...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (23): jcs216804.
Published: 30 November 2018
..., but also in quiescent, senescent and terminally differentiated cells. During mitosis, residual endocytosis is dedicated to the internalization of caveolae and specific receptors. In non-dividing cells, clathrin-mediated endocytosis (CME) functions, but the activity of alternative processes...
Journal Articles
J Cell Sci (2018) 131 (12): jcs214726.
Published: 25 June 2018
... cellular senescence in several cancer cell lines. Senescence triggered by cyclin D1 depletion was more extensive than that caused by the prolonged CDK4 inhibition. Intriguingly, the senescence caused by cyclin D1 depletion was independent of RB status of the cancer cell. We identified a build-up...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (19): 3272–3281.
Published: 1 October 2017
... activator (tPA). Interestingly, serpinB2 levels are increased in senescent cells and serpinB2 is thus considered a senescence biomarker. In this study, by mimicking the elevated levels of serpinB2 in senescent cells, proliferating human fibroblasts were induced into senescence. Senescence induced...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2017) 130 (8): 1413–1420.
Published: 15 April 2017
...Taiki Nagano; Akio Nakashima; Kengo Onishi; Kosuke Kawai; Yuto Awai; Mizuki Kinugasa; Tetsushi Iwasaki; Ushio Kikkawa; Shinji Kamada ABSTRACT Cellular senescence is a complex stress response characterized by permanent loss of proliferative capacity and is implicated in age-related disorders...
Journal Articles
J Cell Sci (2016) 129 (5): 912–920.
Published: 1 March 2016
... of senescence-associated β-galactosidase activity. Investigation of cell cycle factors revealed that transient activation of Nanog correlates with consistent downregulation of the cell cycle inhibitor p27 KIP1 (also known as CDKN1B). By performing chromatin immunoprecipitation analysis, we confirmed bona fide...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 293–304.
Published: 15 January 2015
...William W. Du; Xianmin Li; Tianbi Li; Haoran Li; Azam Khorshidi; Fengqiong Liu; Burton B. Yang ABSTRACT The microRNA miR - 17-92 cluster plays a fundamental role in heart development. The aim of this study was to investigate the effect of a member of this cluster, miR-17, on cardiac senescence. We...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (16): 3738–3745.
Published: 15 August 2013
...Eva Alexander; Dominic G. Hildebrand; Anna Kriebs; Kerstin Obermayer; Marianne Manz; Oliver Rothfuss; Klaus Schulze-Osthoff; Frank Essmann Summary Cellular senescence, a state of sustained cell cycle arrest, has been identified as an important anti-tumor barrier. Senescent cells secrete various...
Journal Articles
J Cell Sci (2012) 125 (2): 376–386.
Published: 15 January 2012
...Jiewei Liu; Kun Xu; Maya Chase; Yuxin Ji; Jennifer K. Logan; Rachel J. Buchsbaum The tumor microenvironment undergoes changes concurrent with neoplastic progression. Cancer incidence increases with aging and is associated with tissue accumulation of senescent cells. Senescent fibroblasts...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (1): 7–17.
Published: 1 January 2012
... functions of many of these miRNAs are still unknown. Recently, various miRNAs have been identified that are up- or down-regulated during mammalian aging by comparing their tissue-specific expression in younger and older mice. In addition, many miRNAs have been implicated in governing senescence in a variety...
Journal Articles
J Cell Sci (2007) 120 (18): 3219–3227.
Published: 15 September 2007
... within the evolutionarily conserved C-terminus of PML-I. This domain contains a predicted exonuclease III fold essential for the targeting of the PML-I C-terminus to nucleolar fibrillar centres. Furthermore, spontaneous or oncogene retrieval-induced senescence is associated with the formation of very...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (16): 2904–2911.
Published: 15 August 2007
... known as Smarca4) by adenoviral transduction. Forced Brg1 expression induced a significant cell cycle arrest of MSCs in culture. This was associated with a huge increase in apoptosis that reached a peak 3 days after transduction. In addition, we observed signs of senescence in cells having ectopic Brg1...
Journal Articles
J Cell Sci (2007) 120 (5): 737–747.
Published: 1 March 2007
... phase in proliferating cells and upon cell cycle exit in quiescence, senescence and differentiation. Upon cell cycle exit LINT-25 accumulated in heterochromatin foci, and LAP2α protein levels were downregulated by proteasomal degradation. Although LAP2α was not required for the upregulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (12): 2435–2443.
Published: 15 June 2006
...S.-H. Kim; J. Rowe; H. Fujii; R. Jones; B. Schmierer; B.-W. Kong; K. Kuchler; D. Foster; D. Ish-Horowicz; G. Peters In mammalian cells, products of the INK4a-ARF locus play major roles in senescence and tumour suppression in different contexts, whereas the adjacent INK4b gene is more generally...
Journal Articles
J Cell Sci (2005) 118 (4): 743–758.
Published: 15 February 2005
...Florence Debacq-Chainiaux; Céline Borlon; Thierry Pascal; Véronique Royer; François Eliaers; Noëlle Ninane; Géraldine Carrard; Bertrand Friguet; Françoise de Longueville; Sophie Boffe; José Remacle; Olivier Toussaint Premature senescence of human diploid fibroblasts (HDFs) can be induced...
Includes: Supplementary data