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Keywords: STIM1
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Journal Articles
In collection:
Imaging
J Cell Sci (2021) 134 (5): jcs252320.
Published: 11 February 2021
... that membrane tubulation at borreliae-containing phagosomes, a process suggested earlier as a mechanism leading to phagosome compaction but hard to visualize in live-cell imaging, is apparently a frequent phenomenon. Finally, we demonstrate that the endoplasmic reticulum (ER) forms multiple STIM1-positive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs244012.
Published: 10 February 2021
... Chen; Claude Ferec; Thierry Capiod; Olivier Mignen ABSTRACT Since deregulation of intracellular Ca 2+ can lead to intracellular trypsin activation, and stromal interaction molecule-1 (STIM1) protein is the main regulator of Ca 2+ homeostasis in pancreatic acinar cells, we explored the Ca 2+ signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs248658.
Published: 27 January 2021
.... Dipeptides [glycyl-L-phenylalanine 2-naphthylamide (GPN) and L-leucyl-L-leucine methyl ester] that are inducers of lysosomal membrane permeabilization (LMP) uncoupled endoplasmic reticulum Ca 2+ -store depletion from SOCE by interfering with Stim1 oligomerization and/or Stim1 activation of Orai. Similarly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs239491.
Published: 29 April 2020
...Liling Niu; Fuyun Wu; Kaili Li; Jing Li; Shenyuan L. Zhang; Junjie Hu; Qian Wang ABSTRACT Store-operated Ca 2+ entry (SOCE) is critical for numerous Ca 2+ -related processes. The activation of SOCE requires engagement between stromal interaction molecule 1 (STIM1) molecules on the endoplasmic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs237388.
Published: 16 March 2020
.... and Balla , T. ( 2009 ). Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides . J. Biol. Chem.   284 , 21027 - 21035 . 10.1074/jbc.M109.012252 Lehto , M. , Mayranpaa , M. I. , Pellinen , T. , Ihalmo , P. , Lehtonen , S. , Kovanen , P. T...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (2): jcs233254.
Published: 23 January 2020
..., but RASSF4 required coexpression with PIP5KIγ to increase plasma membrane PtdIns(4,5) P 2 . Effects on the several steps of store-operated calcium entry (SOCE) were not explained by plasma membrane phosphoinositide increases alone. PIP5KIβ and RASSF4 increased STIM1 proximity to the plasma membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (1): jcs237354.
Published: 8 January 2020
...Sang Kwon Lee; Min-hsun Lee; Su Ji Jeong; Xianan Qin; Ah Reum Lee; Hyokeun Park; Chan Young Park ABSTRACT Store-operated Ca 2+ entry (SOCE) is a major Ca 2+ influx pathway that is controlled by the ER Ca 2+ sensor STIM1. Abnormal activation of STIM1 directly influences Ca 2+ influx, resulting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs227389.
Published: 31 May 2019
... channels of TRPC1 with TRPC4 or TRPC5. This possibility was explored in PC12 cells and guinea pig AM cells. Proximity ligation assay (PLA) revealed that when exogenously expressed in PC12 cells, TRPC1 forms a heteromeric channel with TRPC4, but not with TRPC5, in a STIM1-dependent manner. The heteromeric...
Journal Articles
J Cell Sci (2019) 132 (10): jcs226019.
Published: 15 May 2019
...Esther Lopez; Irene Frischauf; Isaac Jardin; Isabella Derler; Martin Muik; Carlos Cantonero; Gines M. Salido; Tarik Smani; Juan A. Rosado; Pedro C. Redondo ABSTRACT Stromal interaction molecule 1 (STIM1) is one of the key elements for the activation of store-operated Ca 2+ entry (SOCE). Hence...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (17): 2821–2832.
Published: 1 September 2017
...Marek K. Korzeniowski; Eva Wisniewski; Barbara Baird; David A. Holowka; Tamas Balla ABSTRACT Decreased luminal endoplasmic reticulum (ER) Ca 2+ concentration triggers oligomerization and clustering of the ER Ca 2+ sensor STIM1 to promote its association with plasma membrane Orai1 Ca 2+ channels...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3143–3154.
Published: 15 August 2015
...Rawad Hodeify; Senthil Selvaraj; Jennifer Wen; Abdelilah Arredouani; Satanay Hubrack; Maya Dib; Sara N. Al-Thani; Timothy McGraw; Khaled Machaca ABSTRACT The key proteins mediating store-operated Ca 2+ entry (SOCE) are the endoplasmic reticulum (ER) Ca 2+ sensor STIM1 and the plasma membrane Ca 2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (14): 3170–3180.
Published: 15 July 2013
...Eulalia Pozo-Guisado; Vanessa Casas-Rua; Patricia Tomas-Martin; Aida M. Lopez-Guerrero; Alberto Alvarez-Barrientos; Francisco Javier Martin-Romero Summary STIM1 (stromal interaction molecule 1) is a key regulator of store-operated calcium entry (SOCE). Upon depletion of Ca 2+ concentration within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (11): 2401–2410.
Published: 1 June 2013
... through intricate coordination between the Ca 2+ sensor on the ER membrane (stromal interaction molecule 1, STIM1) and the plasma membrane channel Orai1. When Ca 2+ stores are depleted, STIM1 oligomerizes and physically interacts with Orai1 through its SOAR/CAD domain, resulting in Orai1 gating and Ca 2...
Journal Articles
J Cell Sci (2013) 126 (7): 1672–1681.
Published: 1 April 2013
... is downregulated during mouse meiosis, but remains active in mature metaphase II eggs. SOCE inhibition is due to a decreased ability of the Ca 2+ sensor STIM1 to translocate to the cortical endoplasmic reticulum domain and due to internalization of Orai1. Reversing SOCE downregulation by overexpression of STIM1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (2): 667–675.
Published: 15 January 2013
...) in vivo and thus regulates fluid secretion. In Cav1 −/− mouse SG, agonist-stimulated Ca 2+ entry and fluid secretion are significantly reduced. Microdomain localization of TRPC1 and interaction with its regulatory protein, STIM1, are disrupted in Cav1 −/− SG acinar cells, whereas Orai1–STIM1 interaction...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2011) 124 (15): 2602–2610.
Published: 1 August 2011
... cells. In the present study, we find that association of the endoplasmic reticulum (ER) Ca 2+ sensor, STIM1, and the store-operated Ca 2+ channel, Orai1, stimulated by thapsigargin-mediated ER store depletion, is enhanced by overexpression of PIP5KIβ and inhibited by overexpression of PIP5KIγ...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (18): 3084–3093.
Published: 15 September 2010
..., STIM1, a transmembrane protein located in the endoplasmic reticulum (ER), aggregates and relocates close to the plasma membrane (PM) where it activates store-operated calcium channels (SOCs). Although STIM1 was early defined as a phosphoprotein, the contribution of the phosphorylation has been elusive...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (8): 1220–1228.
Published: 15 April 2009
... stimulation and depleted Ca 2+ stores (either due to IP3R-mediated Ca 2+ release or Ca 2+ uptake inhibition) work in concert to activate La 3+ -resistant Ca 2+ entry. This Ca 2+ entry was inhibited by genistein. In addition, BCR-mediated Ca 2+ entry was completely abolished in Stim1-deficient DT40 cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 762–772.
Published: 15 March 2008
...Jeremy T. Smyth; Wayne I. DeHaven; Gary S. Bird; James W. Putney, Jr Stim1 responds to depletion of ER Ca 2+ stores by rearranging from tubular structures throughout the ER into punctate structures near the plasma membrane, where it activates Orai store-operated Ca 2+ entry (SOCE) channels. However...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2007) 120 (12): 1959–1965.
Published: 15 June 2007
... proposed, and there has been considerable interest in the possibility that TRP channels function as store-operated channels. However, in the past two years, two major players in both the signaling and permeation mechanisms for store-operated channels have been discovered: Stim1 and the Orai proteins. Stim1...