...Julian Rapp; Malte Jung; Rhena F. U. Klar; Julian Wolf; Jakob Arnold; Oliver Gorka; Olaf Groß; Clemens Lange; Hansjürgen Agostini; Günther Schlunck; Felicitas Bucher ABSTRACT Aberrant angiogenesis is a hallmark of cardiovascular and retinal neovascular disease. The STAT3 signaling pathway...

... interdependent, they cannot fully substitute for each other. Strikingly, inhibition of any internalization mechanism impaired activation of STAT3 but not of other downstream effectors of PDGFRβ. Our data indicate that multiple routes of internalization of PDGFRβ contribute to a transcriptional and mitogenic...

...Shoudong Ye; Dongming Zhang; Fei Cheng; Daniel Wilson; Jeffrey Mackay; Kan He; Qian Ban; Feng Lv; Saifei Huang; Dahai Liu; Qi-Long Ying ABSTRACT Activation of leukemia inhibitor factor (LIF)–Stat3 or Wnt/β-catenin signaling promotes mouse embryonic stem cell (mESC) self-renewal. A myriad...

... that, during iPSC generation, enhanced Akt1 activity promotes complete reprogramming mainly through increased activation of Stat3 in concert with leukemia inhibitory factor (LIF) and, to a lesser extent, through promotion of colony formation. Akt1 augments Stat3 activity through activation of mTOR...

.... Additional studies revealed that overexpression of manganese superoxide dismutase (MnSOD, officially known as SOD2) and reduced intracellular oxidation played a key role in increased cell migration in p27-deficient cells. Furthermore, we identified signal transducer and activator of transcription 3 (STAT3...

.... Mechanistically, depletion of ptpn9 in zebrafish embryos in vivo or in K562 cells in vitro increased phosphorylated STAT3, and the hyper-phosphorylated STAT3 entrapped and prevented the transcription factors GATA1 and ZBP-89 (also known as ZNF148) from regulating erythroid gene expression. These findings imply...

...Tamás Domoszlai; Antons Martincuks; Dirk Fahrenkamp; Hildegard Schmitz-Van de Leur; Andrea Küster; Gerhard Müller-Newen ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is centrally involved in diverse processes including haematopoiesis, immunity...

...) at room temperature for 1 hour. The blots were washed three times for 10 minutes with TBST before incubating with primary antibody in TBST for 1 hour at room temperature or overnight at 4°C. The primary antibodies STAT5a (Invitrogen, cat. no. 13-3600), STAT3 (K-15; Santa Cruz, cat. no. sc-483), p(Ser...

...Chih-I Tai; Qi-Long Ying Summary Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC) self-renewal and also facilitates reprogramming to ground state pluripotency. Exactly how LIF/Stat3 signaling...

... of necroptosis; with antioxidants and inhibitors of mitochondrial complex I preventing TNF-induced cytotoxicity. However, components of the signaling pathway that lie between activated RIPK-1 and the mitochondria are unknown. In the study reported here we demonstrate that during TNF-induced necroptosis, STAT3...

...Michael Vogt; Tamas Domoszlai; Dzina Kleshchanok; Swen Lehmann; Anne Schmitt; Valeria Poli; Walter Richtering; Gerhard Müller-Newen STAT3 is an important transcription factor involved in immunity and cancer. In response to cytokine stimulation, STAT3 becomes phosphorylated on a single tyrosine...

... that TRIM8 interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL-6-dependent activation of STAT3. Ectopic expression of TRIM8 cancels the negative effect of PIAS3 on STAT3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus...

...Terk Shin Teng; Baohong Lin; Ed Manser; Dominic Chi Hiung Ng; Xinmin Cao Stat3 is a member of the signal transducer and activator of transcription family, which is important for cytokine signaling as well as for a number of cellular processes including cell proliferation, anti-apoptosis and immune...

...Andreas Herrmann; Michael Vogt; Martin Mönnigmann; Thomas Clahsen; Ulrike Sommer; Serge Haan; Valeria Poli; Peter C. Heinrich; Gerhard Müller-Newen Persistent activation of the transcription factor STAT3 has been detected in many types of cancer and plays an important role in tumor progression...

... of STAT. We have previously described a unique pathway inducing keratinocyte proliferation, which is mediated by insulin stimulation and depends on protein kinase C δ (PKCδ). In this study, we assessed STAT3 activation downstream of this pathway and characterized the role of PKCδ activation in STAT3...

...Andreas Herrmann; Ulrike Sommer; Albert L. Pranada; Bernd Giese; Andrea Küster; Serge Haan; W. Becker; Peter C. Heinrich; Gerhard Müller-Newen Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is involved in a variety of biological functions...