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Keywords: SREBP-1c
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2005) 118 (17): 3905–3915.
Published: 1 September 2005
... mechanisms. We found a strong correlation between chronic high-glucose treatment and SREBP-1c activation in INS-1 cells and rat islets. Both high-glucose treatment and SREBP-1c activation in INS-1 cells resulted in lipid accumulation, impaired glucose-stimulated insulin secretion, apoptosis, and strikingly...
