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Keywords: Regeneration
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Journal Articles
J Cell Sci (2022) 135 (6): jcs259664.
Published: 9 March 2022
... ROS production and their integration with signaling pathways remain poorly understood. We focused on the early dialog between H 2 O 2 and Sonic hedgehog (Shh) during zebrafish fin regeneration. We demonstrate that H 2 O 2 controls Shh expression and that Shh in turn regulates the H 2 O 2 level via...
Includes: Supplementary data
Journal Articles
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Stem Cells
J Cell Sci (2022) 135 (4): jcs256008.
Published: 21 February 2022
...Megha Agarwal; Anushree Bharadwaj; Sam J. Mathew ABSTRACT Muscle stem (satellite) cells express Pax7, a key transcription factor essential for satellite cell maintenance and adult muscle regeneration. We identify the corepressor transducin-like enhancer of split-4 (TLE4) as a Pax7 interaction...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs258694.
Published: 12 January 2022
... expression and spatial localization of collagen XI was studied following injury in a Col11a1 inducible knockout mouse model. We found that collagen XI expression occurs during early maturation and is upregulated after stromal injury in areas of regeneration and remodeling. Abnormal fibrillogenesis with new...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (12): jcs242297.
Published: 19 June 2020
...Osvaldo Contreras; Hesham Soliman; Marine Theret; Fabio M. V. Rossi; Enrique Brandan ABSTRACT Mesenchymal stromal cells (MSCs) are multipotent progenitors essential for organogenesis, tissue homeostasis, regeneration and scar formation. Tissue injury upregulates transforming growth factor β (TGF-β...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2020) 133 (8): jcs237545.
Published: 24 April 2020
...Annelies Wouters; Jan-Pieter Ploem; Sabine A. S. Langie; Tom Artois; Aziz Aboobaker; Karen Smeets ABSTRACT Pluripotent stem cells hold great potential for regenerative medicine. Increased replication and division, such is the case during regeneration, concomitantly increases the risk of adverse...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs231993.
Published: 14 November 2019
... they potentiate osteoblast differentiation and bone formation. Here, we use zebrafish caudal fin regeneration as a model to clarify how the Hippo pathway regulates de novo bone formation and osteoblast differentiation. We demonstrate that Yap inhibition leads to accumulation of osteoprogenitors and prevents...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (19): jcs232157.
Published: 9 October 2019
...Osvaldo Contreras; Meilyn Cruz-Soca; Marine Theret; Hesham Soliman; Lin Wei Tung; Elena Groppa; Fabio M. Rossi; Enrique Brandan ABSTRACT Fibro–adipogenic progenitors (FAPs) are tissue-resident mesenchymal stromal cells (MSCs) required for proper skeletal muscle development, regeneration...
Includes: Supplementary data
Journal Articles
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Metabolism
J Cell Sci (2018) 131 (14): jcs212977.
Published: 27 July 2018
...Francesca Pala; Daniela Di Girolamo; Sébastien Mella; Siham Yennek; Laurent Chatre; Miria Ricchetti; Shahragim Tajbakhsh ABSTRACT During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (2): jcs208215.
Published: 29 January 2018
... valuable tools to increase crop regeneration and transformation efficiency. References Aida , M. , Beis , D. , Heidstra , R. , Willemsen , V. , Blilou , I. , Galinha , C. , Nussaume , L. , Noh , Y.-S. , Amasino , R. and Scheres , B. ( 2004 ). The PLETHORA...
Journal Articles
J Cell Sci (2017) 130 (17): 2833–2842.
Published: 1 September 2017
... muscles being more prone to spontaneous regeneration. When the regeneration capacity of the compromised NesKO muscle was tested by muscle injury experiments, a significant healing delay was observed. NesKO satellite cells showed delayed proliferation kinetics in conjunction with an elevation in p35...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (11): 1917–1928.
Published: 1 June 2017
.... Wound repair Regeneration Cell migration Epidermis Giant cell Cell–cell fusion elicits dramatic changes in the genetics and physiology of the participating cells. Chromosomal instability and aberrant gene expression may occur as a result of cell fusion ( Duelli and Lazebnik, 2007 ). Cell...
Includes: Supplementary data
Journal Articles
In collection:
Stem Cells
J Cell Sci (2017) 130 (2): 332–343.
Published: 15 January 2017
...Masahiko Takemura; Hiroshi Nakato ABSTRACT Stem cell division is activated to trigger regeneration in response to tissue damage. The molecular mechanisms by which this stem cell mitotic activity is properly repressed at the end of regeneration are poorly understood. Here, we show that a specific...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism , Stem Cells
J Cell Sci (2015) 128 (24): 4467–4474.
Published: 15 December 2015
... Metabolism Yeast Adult stem cell Signaling pathways Regeneration A distinguishing feature of stem cells is their ability to retain the primal capacity to generate more stem cells whose progeny can have distinct fates, an attribute called (pluri)potency. Uncovering the molecular basis of potency...
Journal Articles
J Cell Sci (2015) 128 (22): 4196–4209.
Published: 15 November 2015
... and is responsible for muscle regeneration, which is associated with the increased expression of myogenin, desmin and embryonic myosin heavy chain during myogenesis, as well as for myotube formation. In conclusion, NRIP is a novel Z-disc protein that is important for skeletal muscle strength and regenerative...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4543–4548.
Published: 1 November 2014
... cells remain in a dormant quiescent state in uninjured muscle, they are poised to activate and produce committed progeny. Unlike committed myogenic progenitor cells, the self-renewal capacity gives muscle stem cells the ability to engraft as satellite cells and capitulate long-term regeneration. Similar...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (3): 599–608.
Published: 1 February 2014
...-injury-induced regeneration in Sharp-1-deficient mice. We show that embryonic skeletal muscle development is not impaired in the absence of Sharp-1; however, post-natally, the regenerative capacity is compromised. Although the initial phases of injury-induced regeneration proceed normally in Sharp-1...
Journal Articles
J Cell Sci (2013) 126 (5): 1122–1133.
Published: 1 March 2013
...-promoting effects of PAK18, modulating PAK function using cell-permeable peptides may be a useful strategy to enhance axon regeneration after injury. PAK primers were designed by inserting the corresponding Xenopus laevis genomic sequences, obtained from Xenbase ( Bowes et al., 2010...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 90–102.
Published: 1 January 2013
... ( jeff.twiss@drexel.edu ). 10 10 2012 © 2013. Published by The Company of Biologists Ltd 2013 RNA transport Axon growth Axonal protein synthesis Regeneration Polarized eukaryotic cells transport mRNAs from the nucleus to subcellular domains, providing a precise spatial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 3957–3965.
Published: 1 September 2012
... improves muscle regeneration and decreases fibrosis in normal skeletal muscle.   Am. J. Sports Med.   36 , 1548 – 1554 . Bernasconi   P. , Torchiana   E. , Confalonieri   P. , Brugnoni   R. , Barresi   R. , Mora   M. , Cornelio   F. , Morandi   L. , Mantegazza   R. ( 1995...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1738–1749.
Published: 1 April 2012
... cells are more primed for myogenic commitment compared with wild-type satellite cells. Paradoxically however, heterotypic transplantation of Myf5 heterozygous cells into regenerating muscles results in higher self-renewal capacity compared with wild-type stem cells, whereas myofibre regenerative...
Includes: Supplementary data