...Adél Sepsi; Trude Schwarzacher ABSTRACT During prophase I of meiosis, homologous chromosomes pair, synapse and exchange their genetic material through reciprocal homologous recombination, a phenomenon essential for faithful chromosome segregation. Partial sequence identity between non-homologous...

... the initiation of meiotic recombination. Meiotic DSB formation is catalyzed by SPO11 and their repair takes place on meiotic chromosome axes. The evolutionarily conserved MEI4 protein is required for meiotic DSB formation and is localized on chromosome axes. Here, we show that HORMAD1, one of the meiotic...

... proteins. Thus, the 9‐1‐1 complex functions to promote two crucial meiotic recombination processes, the regulation of interhomolog recombination and crossover formation mediated by ZMM. To elucidate the role of Rad51‐dependent interhomolog bias in ZMM assembly, we analyzed Zip3 focus formation...

... on crossover distribution, suggesting that Yem has an early role in meiotic recombination. This is further supported by the impact of yem mutations on DSB kinetics. A Hira mutation gave a similar effect, presumably through disruption of Hira–Yem complex. * Present address: Cell Cycle and Cancer Biology...

... to the first meiotic division, homologous recombination (HR) repairs Spo11-dependent DNA double-strand breaks (DSBs) in the presence of telomere movements to allow for chromosome pairing and segregation at the meiosis I division. In contrast to HR, non-homologous end joining (NHEJ), the major DSB repair...

... that is triggered by meiotic DNA double-strand breaks (DSBs), suggesting that the bouquet is needed for DSB repair. However, in the present study we show that although homologous pairing is impeded in the absence of the bouquet, DSB repair takes place nevertheless. Moreover, recombinational DSB repair, as monitored...

... is unknown and the subject of this study. We show that brc1 Δ cells are significantly delayed in recovery from replication pausing, though this does not activate a DNA damage checkpoint. DNA repair and recombination protein Rad52 is a homologous recombination protein that loads the Rad51 recombinase...

.... , West S. C. ( 2008 ). Structural and functional relationships of the XPF/MUS81 family of proteins . Annu. Rev. Biochem. 77 , 259 - 287 . Cromie G. A. , Smith G. R. ( 2007 ). Branching out: meiotic recombination and its regulation . Trends Cell Biol. 17 , 448 - 455...

...Esther Refolio; Santiago Cavero; Edyta Marcon; Raimundo Freire; Pedro A. San-Segundo During meiosis, accurate segregation of intact chromosomes is essential for generating healthy gametes. Defects in recombination and/or chromosome synapsis activate the pachytene checkpoint, which delays meiotic...

... revealed that both pairing and synapsis in the recombinationally suppressed regions still occurred at normal frequencies ( Sherizen et al., 2005 ). Normal levels of pairing and synapsis were also observed in females that were heterozygous for a normal sequence X chromosome and a multiply rearranged...

... Shelterin ALT Aging Recombination Genome stability Telomeres consist of a repetitive non-coding sequence that terminates in a single-stranded overhang at the end of linear chromosomes in eukaryotes and some prokaryotes. Both the overhang and the upstream double-stranded region serve as binding...

...Kazufumi Mochizuki; Maria Novatchkova; Josef Loidl During meiosis, the micronuclei of the ciliated protist Tetrahymena thermophila elongate dramatically. Within these elongated nuclei, chromosomes are arranged in a bouquet-like fashion and homologous pairing and recombination takes place. We...

...Radhika S. Khetani; Sharon E. Bickel During meiosis, cohesion between sister chromatids is required for normal levels of homologous recombination, maintenance of chiasmata and accurate chromosome segregation during both divisions. In Drosophila , null mutations in the ord gene abolish meiotic...

...C. Kerzendorfer; J. Vignard; A. Pedrosa-Harand; T. Siwiec; S. Akimcheva; S. Jolivet; R. Sablowski; S. Armstrong; D. Schweizer; R. Mercier; P. Schlögelhofer Mnd1 has recently been identified in yeast as a key player in meiotic recombination. Here we describe the identification and functional...

...Adela Calvente; Alberto Viera; Jesús Page; M. Teresa Parra; Rocío Gómez; José A. Suja; Julio S. Rufas; Juan L. Santos The relationship between meiotic recombination events and different patterns of pairing and synapsis has been analysed in prophase I spermatocytes of the grasshopper Stethophyma...

... and CESC1 in synaptonemal-complex assembly, and perhaps also stability and recombination. ‡ Author for correspondence (e-mail: howard.cooke@hgu.mrc.ac.uk ) * Present address: Neural Plasticity Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK 23 3 2005 ©...

... was either hampered (zygotic meiosis) or abolished (azygotic meiosis) and the pairing of homologous chromosomes was impaired. Accordingly, the allelic recombination rates of the mcp6 Δ strain were only 10-40% of the wild-type rates. By contrast, the ectopic recombination rate of the mcp6 Δ strain was twice...

...Josef Loidl; Harry Scherthan During meiotic prophase in the ciliate Tetrahymena thermophila micronuclei dramatically elongate and form thread-like crescents. The arrangement of the chromosomes within the crescent as well as the timing of chromosome pairing and recombination with respect...

... presenting homologous DNA regions for homology recognition and recombination and/or the prevention of recombination between sisters. For this purpose, they need not be organized into canonical tripartite SCs or extend all along the chromosomes. If LEs have this function then one would expect them...

... cerevisiae have shown that dicentric chromosome repair occurs primarily by deletion of one centromere via a RAD52 -dependent recombination pathway. We report that dicentric chromosome resolution requires RAD1 , a gene involved in the single-strand annealing DNA repair pathway. We additionally show...