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Keywords: Rab8
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (2): jcs249565.
Published: 22 January 2021
... depletion leads to the inhibition of ciliogenesis, the absence of centrosomal Rab8-positive structures and the accumulation of Arl13B-positive vesicles around the distal appendages. Our results uncover a novel fusion machinery, comprising EFA6A, Arf6 and Arl13B, that controls the coordinated fusion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (20): jcs212498.
Published: 22 October 2018
..., we set out to determine the intracellular localisation of endogenous STX19 and elucidate the mechanism by which it is targeted to membranes. We have found that a pool of STX19 is localised to tubular recycling endosomes where it colocalises with MICAL-L1 and Rab8 (which has Rab8a and Rab8b forms...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1147–1157.
Published: 15 March 2017
... of endocytosis and exocytosis combined with fine-tuning of the local activity of small GTPases like Rab8. Here, we show that endocytic turnover of the plasma membrane at protrusions is directly coupled to surface removal and inactivation of Rab8. Removal is induced by reduced membrane tension and mediated...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (20): 3922–3934.
Published: 15 October 2016
.... Screening known CTSs of ciliary membrane residents uncovered that fibrocystin, photoreceptor retinol dehydrogenase, rhodopsin and retinitis pigmentosa 2 interact with transportin1 (TNPO1) through previously identified CTSs. We further discovered that a new ternary complex, comprising TNPO1, Rab8 and a CTS...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (8): 1734–1749.
Published: 15 April 2016
...José J. Bravo-Cordero; Marco Cordani; Silvia F. Soriano; Begoña Díez; Carmen Muñoz-Agudo; María Casanova-Acebes; César Boullosa; Marta C. Guadamillas; Iakes Ezkurdia; David González-Pisano; Miguel A. del Pozo; María C. Montoya ABSTRACT Rab8 is a small Ras-related GTPase that regulates polarized...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (14): 2541–2552.
Published: 15 July 2015
... by promoting T-cell receptor (TCR) recycling. Here, we have addressed the role of Rab8 (for which there are two isoforms Rab8a and Rab8b), a small GTPase implicated in ciliogenesis, in TCR traffic to the immune synapse. We show that Rab8, which colocalizes with IFT20 in Rab11 + endosomes, is required for TCR...
Journal Articles
J Cell Sci (2015) 128 (8): 1617–1626.
Published: 15 April 2015
... 2 2 2015 © 2015. Published by The Company of Biologists Ltd 2015 Rab11 Rab8 Enterocyte Intestinal polarity Microvilli Syntaxin 3 References Baetz   NW , Goldenring   JR 2013 Rab11-family interacting proteins define spatially and temporally distinct regions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1386–1399.
Published: 1 April 2015
... to Rab8-positive membrane tubules and is required for the integrity of the Rab8 and Golgi compartments. Depletion of DLC3 impairs the transport of internalized transferrin to the endocytic recycling compartment (ERC), which is restored by the simultaneous downregulation of RhoA and RhoB. We further...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1476–1486.
Published: 1 April 2014
... no competing interests. 16 07 2013 8 01 2014 © 2014. Published by The Company of Biologists Ltd 2014 Kidney Cilia Septin 7 sept7b Rab8 Ciliogenesis Vesicle trafficking Septins are a highly conserved family of GTP-binding proteins that polymerize into heteromeric...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5026–5039.
Published: 1 November 2012
...Vipul Vaibhava; Ananthamurthy Nagabhushana; Madhavi Latha Somaraju Chalasani; Cherukuri Sudhakar; Asha Kumari; Ghanshyam Swarup Summary Rab GTPases regulate various membrane trafficking pathways but the mechanisms by which GTPase-activating proteins recognise specific Rabs are not clear. Rab8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (23): 4866–4877.
Published: 1 December 2006
...Katarina Hattula; Johanna Furuhjelm; Jaana Tikkanen; Kimmo Tanhuanpää; Pirjo Laakkonen; Johan Peränen Rab8 has a drastic effect on cell shape, but the membrane trafficking route it regulates is poorly defined. Here, we show that endogenous and ectopically expressed Rab8 is associated...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (5): 991–1004.
Published: 1 March 2002
... cells. A dominant negative approach using a GFP-Myo5c tail construct in HeLa cells reveals that the Myo5c tail selectively colocalizes with and perturbs a membrane compartment containing the transferrin receptor and rab8. Transferrin also accumulates in this compartment, suggesting that Myo5c...
Includes: Supplementary data