...Hardik P. Gala; Debarya Saha; Nisha Venugopal; Ajoy Aloysius; Gunjan Purohit; Jyotsna Dhawan ABSTRACT Adult stem cells persist in mammalian tissues by entering a state of reversible quiescence, referred to as G 0 , which is associated with low levels of transcription. Using cultured myoblasts...

... commitment. Our results indicate that TLE4 represses Pax7-mediated Myf5 transcriptional activation by occupying the −111 kb Myf5 enhancer to maintain quiescence. Loss of TLE4 function causes Myf5 upregulation, an increase in satellite cell numbers and altered differentiation dynamics during regeneration...

... as TJP2) in the polarized epithelium. The distribution of Cx43 is altered by pro-inflammatory breast cancer risk factors such as leptin and high-fat diet, as shown in cell culture and on tissue biopsy sections. The control of polarity-mediated quiescence and MSO may contribute to the tumor-suppressive...

...Isabelle Sagot; Damien Laporte ABSTRACT Most cells, from unicellular to complex organisms, spend part of their life in quiescence, a temporary non-proliferating state. Although central for a variety of essential processes including tissue homeostasis, development and aging, quiescence is poorly...

..., such as quiescent, senescent and terminally differentiated cells, have different endocytic needs and mechanisms from proliferating ones, as the following sections will review. Cellular quiescence (also named ‘G0’ stage of the cell cycle) is the state in which cells are not dividing but retain the ability...

... such example, the quiescent adult mammalian stem cell, and examines concepts underlying our understanding of quiescence that can be attributed to studies in yeast. We discuss the metabolic, signaling and gene regulatory events that control entry and exit into quiescence in yeast. These processes and events...

...-dependent signaling Quiescence Synchronized myoblasts β-catenin TCF APC Skeletal muscle formation occurs through a series of regulated events involving the specification of myoblasts, their expansion, migration, and withdrawal from the cell cycle, culminating in their differentiation...

... phase in proliferating cells and upon cell cycle exit in quiescence, senescence and differentiation. Upon cell cycle exit LINT-25 accumulated in heterochromatin foci, and LAP2α protein levels were downregulated by proteasomal degradation. Although LAP2α was not required for the upregulation...

...) in mammalian sperm cells. Exp. Cell Res. 232 , 29 -41. * Author for correspondence (e-mail: lelievre@purdue.edu ) 6 1 2005 © The Company of Biologists Limited 2005 2005 Nuclear structure Three-dimensional culture Breast Morphogenesis Quiescence Heterochromatin protein...