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Keywords: Proteolysis
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Journal Articles
J Cell Sci (2021) 134 (16): jcs257790.
Published: 18 August 2021
... by multiple proteins, providing insight into the link between WNT signalling and the ubiquitin–proteasome system. ERAD Proteolysis Ubiquitylation EVI/WLS Wnt signalling Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 259332240/RTG 2099 SFB1324 Cell–cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs253088.
Published: 26 July 2021
.../βTrCP-binding (SB) motif is critical for ZYG-1 degradation, substantiating a conserved mechanism by which ZYG-1/Plk4 stability is regulated by the SKP1–CUL1–F-box (Slimb/βTrCP)-protein complex (SCF Slimb/βTrCP )-dependent proteolysis via the conserved SB motif in C. elegans . Furthermore, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (21): jcs249862.
Published: 3 November 2020
... distinct chaperone that forms a tripartite complex with PBAC1 and PBAC2 to promote assembly of the 20S proteasome α-ring in Arabidopsis . Arabidopsis Chaperone Core protease Degradation Evolution Proteasome Proteolysis Proteostasis Regulatory particle Ubiquitin National...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (9): jcs231662.
Published: 7 May 2019
... the recognition of cellular location signals embedded into the P2 residues of most proteins. N-end rule pathway Ubr1 Ubiquitin-mediated degradation Proteolysis Protein quality control Protein misfolding CytoQC N-degron Protein quality control (PQC) is an essential protein quality surveillance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (13): 2208–2219.
Published: 1 July 2011
.... Acad. Sci. USA 91 , 10610 - 10614 . * Authors for correspondence ( ayokoyam@ncc.go.jp ; mcleary@stanford.edu ) ‡ These authors contributed equally to this work 25 2 2011 © 2011. 2011 MLL Degradation Proteolysis The mixed lineage leukemia (MLL) protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (7): 1126–1135.
Published: 1 April 2011
... ) 23 11 2010 © 2011. 2011 Fusion Dynamin-related proteins Mitochondria Proteolysis Ubiquitylation A proper control of membrane dynamics and content mixing between organelles is essential for cellular communication ( Martens and McMahon, 2008 ). Endocytosis and mitochondrial...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2009) 122 (22): 4208–4217.
Published: 15 November 2009
... APC/C Mitosis Proteolysis Cyclin Ubiquitin p53 Replication DNA damage The anaphase-promoting complex/cyclosome (APC/C) is a large multisubunit ubiquitin protein ligase that is essential for sister chromatid separation and exit from mitosis. Because these events are crucial...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 601–608.
Published: 1 March 2008
... to inhibit Spg1p signalling. * Author for correspondence (e-mail: viesturs.simanis@isrec.ch ) 19 11 2007 © The Company of Biologists Limited 2008 2008 Cytokinesis S. pombe GTPase activating protein (GAP) Proteolysis Coordination of mitosis and cytokinesis is important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (10): 1977–1984.
Published: 15 May 2006
... function and, when deregulated, leads to the development of diseases such as polyQ disorders and other neurodegenerative conditions. e-mail: mikecz@uni-duesseldorf.de 4 4 2006 © The Company of Biologists Limited 2006 2006 Cell nucleus Proteasome Protein aggregation Proteolysis...
Journal Articles
J Cell Sci (2005) 118 (22): 5231–5242.
Published: 15 November 2005
... nuclear proteolysis. Here, fluorogenic precursor substrates enabled detection of proteasomal activity in nucleoplasmic cell fractions (turnover 0.0541 μM/minute) and nuclei of living cells (turnover 0.0472 μM/minute). By contrast, cell fractions of nucleoli or nuclear envelopes did not contain proteasomal...
Journal Articles
J Cell Sci (2005) 118 (17): 3829–3838.
Published: 1 September 2005
... of calpain activity. Knockout and knockdown approaches have also contributed significantly to our knowledge of calpain biology, particularly with respect to the specific functions of different calpain isoforms. The mechanisms by which calpain-mediated proteolysis of individual substrates contributes to cell...
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J Cell Sci (2002) 115 (14): 3007–3014.
Published: 15 July 2002
...,suggesting that the Ubc6p function is highly conserved from yeast to mammals. ‡ Author for correspondence (e-mail: tsommer@mdc-berlin.de ) 10 5 2002 © The Company of Biologists Limited 2002 2002 Endoplasmic reticulum Ubiquitin Proteolysis Protein folding...
Journal Articles
J Cell Sci (2001) 114 (13): 2491–2499.
Published: 1 July 2001
... Proteolysis Chaperone Translocation Transport Many intracellular proteins must be translocated across a membrane before they reach their proper intracellular location. Mechanisms of protein secretion across the plasma membrane of bacteria ( Nishiyama et al., 1999 ; Bernstein, 2000 ) as well...
Journal Articles
J Cell Sci (2001) 114 (11): 2135–2143.
Published: 1 June 2001
... to the formation of spores. An mfr1 null mutant completes meiosis II but remains with high levels of cdc13 and cdc2 kinase activity and has considerably delayed spore formation. By analogy with the mitotic cell cycle, where proteolysis and inactivation of cdc2 kinase are necessary to trigger mitotic exit...
Journal Articles
J Cell Sci (2001) 114 (1): 111–118.
Published: 1 January 2001
... Pintelaan 185, B-9000 Ghent, Belgium ‡ Author for correspondence ( e-mail: marc.mareel@rug.ac.be ) © 2001 by Company of Biologists 2001 E-cadherin/catenin complex Ectodomain shedding Matrix metalloproteinase Proteolysis Invasion E-cadherin is a calcium-dependent cell-cell...
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