... to transfer cholesterol and phosphatidylserine between the endoplasmic reticulum (ER) and other organelle membranes. Here, we show that plasma membrane (PM) association of ORP3 (also known as OSBPL3), a poorly characterized ORP family member, is triggered by protein kinase C (PKC) activation, especially when...

...Yosuke Senju; Eva Rosenbaum; Claudio Shah; Sayaka Hamada-Nakahara; Yuzuru Itoh; Kimiko Yamamoto; Kyoko Hanawa-Suetsugu; Oliver Daumke; Shiro Suetsugu ABSTRACT PACSIN2, a membrane-sculpting BAR domain protein, localizes to caveolae. Here, we found that protein kinase C (PKC) phosphorylates PACSIN2...

... and DAG (diacylglycerol) generation. Polarized DAG generation at the IS allows selective activation of a broad range of effectors, including kinases of the PKC and PKD (protein kinase C, D) families, the Ras GEF (guanine nucleotide exchange factor) RasGRP1, and the Rac GAP β2chimaerin ( Almena and Mérida...

...Mohamed M. Bekhite; Andreas Finkensieper; Stephanie Binas; Jörg Müller; Reinhard Wetzker; Hans-Reiner Figulla; Heinrich Sauer; Maria Wartenberg VEGF-, phosphoinositide 3-kinase (PI3K)- and protein kinase C (PKC)-regulated signaling in cardiac and vascular differentiation was investigated in mouse...

... near this polybasic region, potentially by protein kinase C, releases SH2B1β from the PM and enhances nuclear entry. Release of SH2B1β from the PM and/or nuclear entry appear to be required for SH2B1β enhancement of nerve growth factor (NGF)-induced expression of urokinase plasminogen activator...

... ERK regulation in single intact cells, we find that, when protein kinase C or epidermal growth factor receptors are activated, a substantial fraction of the ERK nuclear localization response is uncoupled from TEY phosphorylation. This phosphorylation-unattributable nuclear localization response occurs...

... element (ARE) and activates defensive gene expression, which protects cells. Controversies exist regarding the role of antioxidant-induced modification of INrf2 cysteine 151 or protein kinase C (PKC)-mediated phosphorylation of Nrf2 serine 40 in the release of Nrf2 from INrf2. In addition, the PKC isoform...

...-mail: mochly@stanford.edu ) 19 12 2007 © The Company of Biologists Limited 2008 2008 Protein kinase C Apoptosis Abl Endoplasmic reticulum Mitochondria Endoplasmic reticulum (ER) functions can be impaired by various intracellular and extracellular stimuli that lead to ER stress...

... the development of cancer. The key mechanism in regulation of the Wnt/β-catenin pathway is the amino-terminal phosphorylation of β-catenin, marking it for proteasomal degradation. Here we present small-molecule-based identification of protein kinase C (PKC)-mediated β-catenin phosphorylation as a novel mechanism...

... populations. Toxoplasma gondii Interleukin 12 Mitogen-activated protein kinase Ca 2+ Macrophage/monocyte Protein kinase C © The Company of Biologists Limited 2006 2006 8 8 2006 * Author for correspondence (e-mail: chunter@vet.upenn.edu ) Fig. 4. Ca 2...

... is accompanied by relocalisation of protein kinase C α to desmosomal plaques suggesting that an `inside-out' transmembrane signal is responsible for changing desmosomal adhesiveness. We model hyper-adhesive desmosomes using the crystal packing observed for the ectodomain of C-cadherin and show how the regularity...

.../cyclosome. The signal transduction pathway is not fully resolved but both protein kinase C (PKC) and calmodulin-dependent protein kinase II (CamKII) activities increase at fertilization and previous pharmacological studies have implicated both in cell-cycle resumption. We have used a combination...

..., Israel 20 1 2005 © The Company of Biologists Limited 2005 2005 Endocytic recycling compartment (ERC) Endocytosis Synaptotagmin Protein kinase C RBL-2H3 mast cells Synaptotagmins (Syts) constitute a family of structurally related and ubiquitously expressed proteins...

...Xupei Huang; Jeffery W. Walker Regulatory proteins on muscle filaments are substrates for protein kinase C (PKC) but mechanisms underlying activation and translocation of PKC to this non-membrane compartment are poorly understood. Here we demonstrate that the epsilon isoform of PKC (ϵ-PKC...

...Corinne Quittau-Prévostel; Nathalie Delaunay; Alejandra Collazos; Alice Vallentin; Dominique Joubert Protein kinase C (PKC) has been implicated in the control of intercellular adhesion. Our previous observation demonstrating that activated PKC alpha (PKCα is selectively targeted to cell-cell...

... could be blocked by the simultaneous addition of nocodazole or taxol and depended on Ca 2+ release from intracellular stores since Ca 2+ -mobilizing agents such as thapsigargin and cyclopiazonic acid could induce the redistribution. Furthermore, various protein kinase C inhibitors could inhibit...

... of protein kinase C, but not that of actin polymerization, inhibited the PINCH-ILK-CH-ILKBP complex formation, suggesting that the PINCH-ILK-CH-ILKBP complex likely serves as a downstream effector of protein kinase C in the cellular control of focal adhesion assembly. Finally,we provide evidence...

...Nils Brose; Christian Rosenmund Diacylglycerol is an essential second messenger in mammalian cells. The most prominent intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong to the protein kinase C (PKC) family. However,at least five alternative types...

... 2002 Protein kinase C Synaptotagmin TPA Mast cells Endosome Protein kinase C (PKC) is a family of Ser/Thr kinases that plays a pivotal role in mediating cellular response cascades, including ones for growth and differentiation ( Mellor and Parker,1998 ). PKC isoforms include the Ca 2...

... and microvilli of A431 cells after treatment with EGF. However, A431 cells expressing dominant-negative c-Jun (TAM67), and which as a consequence fail to invade in response to EGF, also fail to correctly localise CD44 and ezrin. CD44 and ezrin are both substrates for Protein Kinase C, and we show that their EGF...