...Fatma Özgün; Zeynep Kaya; Tunç Morova; Bart Geverts; Tsion E. Abraham; Adriaan B. Houtsmuller; Martin E. van Royen; Nathan A. Lack ABSTRACT Androgen receptor (AR) splice variants are proposed to be a potential driver of lethal castration-resistant prostate cancer. AR splice variant 7 (ARv7...

...Robert L. Satcher; Tianhong Pan; Mehmet A. Bilen; Xiaoxia Li; Yu-Chen Lee; Angelica Ortiz; Andrew P. Kowalczyk; Li-Yuan Yu-Lee; Sue-Hwa Lin ABSTRACT Cadherin-11 (Cad11) cell adhesion molecule plays a role in prostate cancer cell migration. Because disassembly of adhesion complexes through...

... . 10.1016/j.yexcr.2010.02.007 Kleeberger   W. , Bova   G. S. , Nielsen   M. E. , Herawi   M. , Chuang   A-Y. , Epstein   J. I. , Berman   D. M. ( 2007 ). Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis.   Cancer Res...

...Zhipeng Zou; Fangyin Zeng; Wanfu Xu; Chunxia Wang; Zhiyong Ke; Q. Jane Wang; Fan Deng Summary Although protein kinase D3 (PKD3) has been shown to contribute to prostate cancer cell growth and survival, the role of PKD in prostate cancer cell motility remains unclear. Here, we show that PKD2...

... Aurora A substrates are mitotic targets, Aurora A autophosphorylation is used as a pharmacodynamic biomarker. Our data show that LIMK2 is highly expressed in breast cancer and prostate cancer due to Aurora A kinase activity. Aurora A inhibition rapidly degrades LIMK2 (half-life ∼2 hours), suggesting...

... adhesions. We now report that DU145 human prostate cancer cells with reduced levels of PAK4 expression are unable to successfully migrate in response to HGF, have prominent actin stress fibres, and an increase in the size and number of focal adhesions. Moreover, these cells have a concomitant reduction...

... that pathological mutations within the NLS of AR that are associated with prostate cancer and androgen-insensitivity syndrome reduce the binding affinity to importin-α and, subsequently, retard nuclear import; surprisingly, however, the transcriptional activity of these mutants varies widely. Thus, in addition...

...Pascal Farla; Remko Hersmus; Jan Trapman; Adriaan B. Houtsmuller The androgen receptor (AR) is essential for development of the male gender and in the growth of the majority of prostate cancers. Agonists as well as most antagonists induce translocation of the receptor to the nucleus, whereas only...

... to this work 19 4 2004 © The Company of Biologists Limited 2004 2004 Prostate cancer Translocon Puromycin Calcium leak Endoplasmic reticulum LNCaP cells The endoplasmic reticulum (ER) plays an essential role in the folding and maturation of proteins and is also the largest...

... 2002 NF-κB IκBα phosphorylation IKK Prostate cancer The signaling pathways that regulate cell proliferation, survival and transformation are of prime interest in cancer biology. Recently, the Rel/NF-κB transcription factors, the known regulators of immune and inflammatory responses...