... and mechanically integrate cells across tissues, dissipating mechanical stress. They comprise five major protein classes – desmocollins and desmogleins (the desmosomal cadherins), plakoglobin, plakophilins and desmoplakin – whose individual contribution to the structure and turnover of desmosomes is poorly...

... signaling regulates the phosphorylation-dependent association of plakophilins 1 and 3 (PKP1 and PKP3) with 14-3-3 protein isoforms, and uncover unique and partially antagonistic functions of members of the 14-3-3 family in the regulation of desmosomes. 14-3-3γ associated primarily with cytoplasmic PKP1...

... with a host of desmosomal plaque proteins, including plakophilins, plakoglobin and desmoplakin, which, in turn, recruit the intermediate filament cytoskeleton to sites of cell–cell contact. Although the individual components of the desmosome are known, mechanisms regulating the assembly of this junction...

... formation by regulating the balance between adhesion and proliferation is not well understood. The desmosomal protein plakophilin 1 can increase intercellular adhesion by recruiting desmosomal proteins to the plasma membrane or stimulate proliferation by enhancing translation rates. Here, we show...

... between αT-catenin and plakophilins was observed and subsequently confirmed by co-immunoprecipitation and colocalization. Interaction with the amino-terminal part of plakophilins appeared to be specific for the central `adhesion-modulation' domain of αT-catenin. In addition, we showed, by immuno-electron...

... Cadherin Plakoglobin Plakophilin Pemphigus Keratoderma Cardiomyopathy Desmosomes are intercellular junctions that connect intermediate filaments to the cell surface and mediate strong cell-cell adhesion. They are particularly prominent in stratified squamous epithelia and the myocardium...

...Mechthild Hatzfeld; Kathleen J. Green; Helmut Sauter p0071, a member of the armadillo protein family, is most closely related to p120 ctn and the plakophilins 1-3. Whereas plakophilins are desmosomal plaque proteins, p120 ctn localizes to adherens junctions and interacts with classical cadherins...