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Lalit Sehgal, Amitabha Mukhopadhyay, Anandi Rajan, Nileema Khapare, Mugdha Sawant, Sonali S. Vishal, Khyati Bhatt, Srikant Ambatipudi, Noelle Antao, Hunain Alam, Mansa Gurjar, Srikanta Basu, Rohit Mathur, Lalit Borde, Amol S. Hosing, Milind M. Vaidya, Rahul Thorat, Felipe Samaniego, Ullas Kolthur-Seetharam, Sorab N. Dalal
J Cell Sci (2014) 127 (10): 2174–2188.
Published: 15 May 2014
...-Seetharam; Sorab N. Dalal ABSTRACT The regulation of cell–cell adhesion is important for the processes of tissue formation and morphogenesis. Here, we report that loss of 14-3-3γ leads to a decrease in cell–cell adhesion and a defect in the transport of plakoglobin and other desmosomal proteins to the cell...
Includes: Supplementary data
J Cell Sci (2013) 126 (14): 3031–3042.
Published: 15 July 2013
...Zackie Aktary; Stephen Kulak; John Mackey; Nadia Jahroudi; Manijeh Pasdar Summary Plakoglobin (γ-catenin), a constituent of the adherens junction and desmosomes, has signaling capabilities typically associated with tumor/metastasis suppression through mechanisms that remain undefined. To determine...
Includes: Supplementary data
J Cell Sci (2012) 125 (13): 3202–3209.
Published: 1 July 2012
.... Loss of Rnd3 expression is also associated with resistance to cisplatin-mediated apoptosis in keratinocytes and this resistance is mediated through the desmosomal protein plakoglobin. We propose a novel plakoglobin-dependent role for Rnd3 in the regulation of keratinocyte cell death. To rescue...
J Cell Sci (2006) 119 (5): 797–806.
Published: 1 March 2006
... Cadherin Plakoglobin Plakophilin Pemphigus Keratoderma Cardiomyopathy Desmosomes are intercellular junctions that connect intermediate filaments to the cell surface and mediate strong cell-cell adhesion. They are particularly prominent in stratified squamous epithelia and the myocardium...
J Cell Sci (2003) 116 (7): 1219–1233.
Published: 1 April 2003
...-desmosomal cadherins. Head and armadillo repeat domains both interacted with plakoglobin by binding to different sites. Our data suggest that, in addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between...
Horst Posthaus, Lina Williamson, Dominique Baumann, Rolf Kemler, Reto Caldelari, Maja M. Suter, Heinz Schwarz, Eliane Müller
J Cell Sci (2002) 115 (23): 4587–4595.
Published: 1 December 2002
... expression occur independently of β-catenin and correlate with repression of transcription from Tcf/Lef-responsive promoters. Moreover, during differentiation,β-catenin-null cells assemble normal intercellular adhesion junctions owing to the substitution of β-catenin with plakoglobin, whereas the expression...
Elayne A. Bornslaeger, Lisa M. Godsel, Connie M. Corcoran, Jung K. Park, Mechthild Hatzfeld, Andrew P. Kowalczyk, Kathleen J. Green
J Cell Sci (2001) 114 (4): 727–738.
Published: 15 February 2001
... demonstrate the existence of a Triton-soluble complex of proteins containing full length desmoplakin (DP), the arm protein plakoglobin, and the cytoplasmic domain of the desmosomal cadherin, desmoglein 1 (Dsg1). In addition, full length DP, but not an N-terminal plakoglobin binding domain of DP, co...
J Cell Sci (2000) 113 (18): 3127–3139.
Published: 15 September 2000
...Jacob Zhurinsky; Michael Shtutman; Avri Ben-Ze′ev ABSTRACT β-Catenin can play different roles in the cell, including one as a structural protein at cell-cell adherens junctions and another as a transcriptional activator mediating Wnt signal transduction. Plakoglobin (γ-catenin), a close homolog...
James K. Wahl, Jill E. Nieset, Paula A. Sacco-Bubulya, Tammy M. Sadler, Keith R. Johnson, Margaret J. Wheelock
J Cell Sci (2000) 113 (10): 1737–1745.
Published: 15 May 2000
...James K. Wahl; Jill E. Nieset; Paula A. Sacco-Bubulya; Tammy M. Sadler; Keith R. Johnson; Margaret J. Wheelock ABSTRACT Beta-catenin and plakoglobin are members of the armadillo family of proteins and were first identified as components of intercellular adhering junctions. In the adherens junction...
J Cell Sci (1998) 111 (14): 1941–1949.
Published: 30 July 1998
...Nikolai A. Chitaev; Alexander Z. Averbakh; Regina B. Troyanovsky; Sergey M. Troyanovsky ABSTRACT Different epithelial intercellular junctions contain distinct complexes incorporating plakoglobin. In adherens junctions, plakoglobin interacts with two molecules, the transmembrane adhesion protein...
J Cell Sci (1998) 111 (4): 495–509.
Published: 15 February 1998
... structure containing a few major proteins including desmoplakins and the armadillo family member plakoglobin. Desmosomal cadherins are putative cell-cell adhesion molecules and we have tested their adhesive capacity using a transfection approach in mouse L cells. We find that L cells expressing either one...
J Cell Sci (1998) 111 (20): 3109–3118.
Published: 15 January 1998
...Diana Fleckenstein; Manfred Rohde; Daniel J. Klionsky; Manfred Rüdiger ABSTRACT Proteins of the armadillo family are involved in diverse cellular processes in higher eukaryotes. Some of them, like armadillo , β-catenin and plakoglobins have dual functions in intercellular junctions and signalling...
J Cell Sci (1997) 110 (19): 2359–2371.
Published: 1 October 1997
...Helena L. Palka; Kathleen J. Green ABSTRACT Plakoglobin, a member of the armadillo family of proteins, is a component of intercellular adhesive junctions. The central domain of plakoglobin comprises a highly conserved series of armadillo repeats that facilitate its association with either...
J Cell Sci (1997) 110 (8): 1013–1022.
Published: 15 April 1997
... with the cytoskeleton via cytoplasmic proteins known as catenins. Three catenins, α-catenin, β-catenin and γ-catenin (also known as plakoglobin), have been identified. β-catenin or plakoglobin is associated directly with the cadherin; α-catenin binds to β-catenin/plakoglobin and serves to link the cadherin/catenin...
J Cell Sci (1996) 109 (13): 3069–3078.
Published: 15 December 1996
...Regina B. Troyanovsky; Nikolai A. Chitaev; Sergey M. Troyanovsky ABSTRACT Plakoglobin directly interacts with cadherins and plays an essential role in the assembly of adherens junctions and desmosomes. Recently we have reported that multiple cadherin binding sites are localized along the arm repeat...
James K. Wahl, Paula A. Sacco, Tammy M. McGranahan- Sadler, Laura M. Sauppé, Margaret J. Wheelock, Keith R. Johnson
J Cell Sci (1996) 109 (5): 1143–1154.
Published: 1 May 1996
... with cytoplasmic proteins that serve to link the cadherin to the cytoskeleton. One component of both adherens junctions and desmosomes is plakoglobin. In the adherens junction plakoglobin interacts with both the classical cadherin and with αcatenin. Alphacatenin in turn interacts with microfilaments. The role...
J Cell Sci (1994) 107 (5): 1241–1254.
Published: 1 May 1994
... plaques was observed in subconfluent cultures. (2) Staining for vinculin was reduced in cell-cell adhesions situated at the apical region of subconfluent, confluent and postconfluent mono- layers. Staining for F-actin and plakoglobin was retained at this region in estradiol-induced cells. (3) vinculin...
J Cell Sci (1993) 105 (4): 923–934.
Published: 1 August 1993
...-cadherin associates with the ơ- and β-catenin proteins. However, the γ-catenin/plakoglobin component could not be detected in the E-cadherin immunocomplexes of the spindle transfectant cells, in contrast to the epithelial cells where the three catenins appeared to be associated with E-cadherin. The lack...
J Cell Sci (1993) 104 (3): 751–762.
Published: 1 March 1993
... studies have suggested that either β- or γ-catenin may be identical to plakoglobin, a protein associated with adherens junctions. However, the relationship between these proteins, and their interaction with cadherins, are not well understood. In this study, we have further defined the relationship between...