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Keywords: Photoreceptors
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Journal Articles
J Cell Sci (2022) 135 (1): jcs259187.
Published: 10 January 2022
... development in two models of embryonic hyperglycemia in zebrafish. Strikingly, we found that hyperglycemic larvae displayed a significant reduction in photoreceptors and horizontal cells, whereas other retinal neurons were not affected. We also observed reactive gliosis and abnormal optokinetic responses...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs238790.
Published: 6 April 2020
... mechanisms of polarized transport have not been elucidated. Drosophila photoreceptor offers an excellent model for studying this. We found that Rab10 impairment significantly reduced basolateral levels of Na + K + ATPase, mislocalizing it to the stalk membrane, which is a domain of the apical plasma membrane...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (22): 4039–4045.
Published: 15 November 2015
...Robert S. Molday; Orson L. Moritz ABSTRACT Retinal photoreceptor cells contain a specialized outer segment (OS) compartment that functions in the capture of light and its conversion into electrical signals in a process known as phototransduction. In rods, photoisomerization of 11- cis to all- trans...
Includes: Supplementary data
Journal Articles
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Lipid Biology
J Cell Sci (2014) 127 (5): 1138–1149.
Published: 1 March 2014
...Jonathan A. Coleman; Xianjun Zhu; Hidayat R. Djajadi; Laurie L. Molday; Richard S. Smith; Richard T. Libby; Simon W. M. John; Robert S. Molday ABSTRACT ATP8A2 is a P 4 -ATPase that is highly expressed in the retina, brain, spinal cord and testes. In the retina, ATP8A2 is localized in photoreceptors...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5725–5734.
Published: 15 December 2013
...Christiana L. Cheng; Robert S. Molday Summary In photoreceptors, the assembly of signaling molecules into macromolecular complexes is important for phototransduction and maintaining the structural integrity of rod outer segments (ROSs). However, the molecular composition and formation...
Journal Articles
J Cell Sci (2013) 126 (14): 3204–3213.
Published: 15 July 2013
...Prachee Avasthi; Jan Frederik Scheel; Guoxin Ying; Jeanne M. Frederick; Wolfgang Baehr; Uwe Wolfrum Summary Centrins are calmodulin-like Ca 2+ -binding proteins that can be found in all ciliated eukaryotic cells from yeast to mammals. Expressed in male germ cells and photoreceptors, centrin 1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1352–1361.
Published: 1 May 2009
... in the retinae of mice lacking Cplx3 and Cplx4, with a significant proportion of photoreceptor terminals containing spherical free-floating ribbons. These structural and functional aberrations were accompanied by behavioural deficits indicative of a vision deficit. Our results show that Cplx3 and Cplx4...
Journal Articles
J Cell Sci (2004) 117 (24): 5825–5834.
Published: 15 November 2004
...Jennifer Lin-Jones; Ed Parker; Mike Wu; Andréa Dosé; Beth Burnside Myo3A, a class III myosin, localizes to the distal (plus) ends of inner segment actin filament bundles that form the core of microvillus-like calycal processes encircling the base of the photoreceptor outer segment. To investigate...