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Keywords: Phase separation
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Journal Articles
Journal Articles
J Cell Sci (2022) 135 (24): jcs260284.
Published: 15 December 2022
... by liquid–liquid phase separation. An intrinsically disordered region (IDR) at the N-terminus is essential for Dvl2 phase separation. Importantly, we identified the HECT-E3 ligase WWP2 as an essential driver of Dvl2 phase separation in vitro and in cells. We demonstrated that ubiquitylation of Dvl2 through...
Includes: Supplementary data
Journal Articles
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (18): jcs259156.
Published: 28 September 2021
... Processing bodies Membraneless granules Phase separation Endoplasmic reticulum Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung http://dx.doi.org/10.13039/501100001711 310030B_163480 310030_185127 Universität Basel http://dx.doi.org/10.13039/100008375...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (17): jcs258685.
Published: 6 September 2021
...Chujun Zhang; Wessel van Leeuwen; Marloes Blotenburg; Angelica Aguilera-Gomez; Sem Brussee; Rianne Grond; Harm H. Kampinga; Catherine Rabouille ABSTRACT The phase separation of the non-membrane bound Sec bodies occurs in Drosophila S2 cells by coalescence of components of the endoplasmic reticulum...
Includes: Supplementary data
Journal Articles
In collection:
Lipid Biology
J Cell Sci (2022) 135 (5): jcs256529.
Published: 17 May 2021
...Tetsuo Mioka; Tian Guo; Shiyao Wang; Takuma Tsuji; Takuma Kishimoto; Toyoshi Fujimoto; Kazuma Tanaka ABSTRACT Membrane phase separation to form micron-scale domains of lipids and proteins occurs in artificial membranes; however, a similar large-scale phase separation has not been reported...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs250191.
Published: 26 January 2021
... Summary: Pmk1 regulates Pck2 recruitment into stress granules (SGs) upon heat stress, which intercepts MAPK signaling activation, indicating that SGs sequester active Pck2 in a feedback mechanism. PKC Stress granules MAPK signaling Spatiotemporal regulation Heat stress Phase separation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs247916.
Published: 8 January 2021
.... , Rousseau , F. , Schymkowitz , J. , Shorter , J. , Wolozin , B. , Van Den Bosch , L. et al. ( 2018 ). Protein phase separation: a new phase in cell biology . Trends Cell Biol. 28 , 420 - 435 . 10.1016/j.tcb.2018.02.004 Boija , A. , Klein , I. A. , Sabari , B. R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (22): jcs235093.
Published: 21 November 2019
...Amy R. Strom; Clifford P. Brangwynne ABSTRACT Cells organize membrane-less internal compartments through a process called liquid–liquid phase separation (LLPS) to create chemically distinct compartments, referred to as condensates, which emerge from interactions among biological macromolecules...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2018) 131 (21): jcs222836.
Published: 5 November 2018
... as how its deregulation is involved in multiple human diseases. p62 Sqstm1 Selective autophagy Phase separation Keap1–Nrf2 system Proteinopathies References Adams , O. , Dislich , B. , Berezowska , S. , Schläfli , A. M. , Seiler , C. A. , Kroell , D...
Journal Articles
J Cell Sci (2018) 131 (4): jcs202002.
Published: 14 February 2018
...) granules. RNP granules assemble through a concentration-dependent liquid–liquid phase separation of RNA-binding proteins that contain low-complexity sequence domains (LCDs). Interestingly, many factors that regulate microRNA (miRNA) biogenesis and alternative splicing are RNA-binding proteins that contain...
Journal Articles
J Cell Sci (2017) 130 (17): 2789–2796.
Published: 1 September 2017
... emerging evidence suggesting that condensed states of living matter regulate intracellular organization, metabolism, signaling and stress adaptation. Intracellular organization Membrane-less compartment Phase separation The paradigm of molecular biology has propelled us forward for many...
Journal Articles
J Cell Sci (2016) 129 (21): 3963–3970.
Published: 1 November 2016
...) in macromolecular phase separation. Potential contributions of HEAT–HEAT interactions, as well as cooperation between HEATs and IDRs, to mesoscale organelle assembly will be discussed. * Authors for correspondence ( yoshimura@lif.kyoto-u.ac.jp ; hiranot@riken.jp ) Competing interests The authors...