... LDs and highlight knowledge gaps that need to be filled in future studies. Fig. 4. Functional consequences of nLD formation. (A) nLD formation may result in a subsequent decrease of the concentration of partner proteins in PML nuclear bodies and thus a potential modulation of their function. (B...

...-mediated histone H3.3 chromatin assembly. This suggests that PML coordinates H3.3 deposition with DNA replication at heterochromatin. Histone H3.3 PML nuclear body PML DAXX ATRX SUMOylation Chromatin organization plays an essential role in establishing cellular identity and maintaining...

... it to be a giant PML nuclear body (PML-NB). The structural integrity of PML-NBs is of major importance for normal cell functioning. Nevertheless, the structural organisation and the functions of these nuclear bodies remain unclear. Here, we take advantage of the large size of the giant body to demonstrate...

...Graham Dellaire; Reagan W. Ching; Hesam Dehghani; Ying Ren; David P. Bazett-Jones Promyelocytic leukemia (PML) nuclear bodies have been implicated in a variety of cellular processes including apoptosis, tumour suppression, anti-viral response, DNA repair and transcriptional regulation. PML nuclear...

... of Biologists Limited 2001 2001 Immuno-FISH Major histocompatibility complex Nuclear organisation PML nuclear body Transcription The mammalian interphase nucleus is responsible for tasks such as DNA replication, control of gene expression, transcription and RNA processing. Despite the absence...