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Keywords: PI3-K
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Journal Articles
J Cell Sci (2003) 116 (21): 4409–4417.
Published: 1 November 2003
... of phosphoinositide 3-kinase (PI3-K), LY294002, blocked the phosphorylation of Akt and increased the sensitivity to apoptosis. LY294002 had no effect on the migration of restricted cells. This suggests that migrating glioma cells activate the PI3-K survival pathway, protecting migrating cells from apoptosis. Taken...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (20): 3599–3606.
Published: 15 October 2001
... second receptor component (Rec) activates a pertussis-toxin sensitive heterotrimeric G protein (1), which interacts via PI3-K (2) with surface GRC (3) to induce Ca 2+ influx (4). The increase in Ca 2+ leads to activation of CaMK (5), which possibly together with PI3-K (?), triggers shuttling of more...