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Keywords: PAK
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Journal Articles
J Cell Sci (2019) 132 (10): jcs217869.
Published: 21 May 2019
... important and complex these regulations can be during epithelial morphogenesis. This complexity is mirrored by the fact that Cdc42 can exert its function through many effector proteins. In epithelial cells, these include atypical PKC (aPKC, also known as PKC-3), the P21-activated kinase (PAK) family...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (10): 1663–1673.
Published: 15 May 2010
... drives prostate cancer cell migration downstream of HGF . Cell. Signal. 20 , 1320 - 1328 . Arias-Romero L. E. , Chernoff J. ( 2008 ). A tale of two Paks . Biol. Cell 100 , 97 - 108 . Bailly M. , Jones G. E. ( 2003 ). Polarised migration: cofilin holds the front...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (11): 1812–1822.
Published: 1 June 2009
..., but not Fyn or Lyn, results in significant inhibition of EC lumen formation. Concurrent with Cdc42 activation, PKCϵ- and SFK-dependent signaling converge to activate p21-activated kinase (Pak)2 and Pak4 in steps that are also required for EC lumen formation. Pak2 and Pak4 further activate two Raf kinases, B...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (17): 2805–2813.
Published: 1 September 2008
... was mediated in part by Pak. Elucidation of this novel pathway for regulation of the fascin/PKCγ complex in migrating carcinoma cells suggests novel targets for therapeutic intervention in metastasis. * Authors for correspondence (e-mail: adamsj@ccf.org ; maddy.parsons@kcl.ac.uk ) 13 5 2008...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (7): 989–1001.
Published: 1 April 2008
.... and Wang, D. L. ( 2001 ). Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain. J. Biol. Chem. 276 , 31368 -31375. Chong, C., Tan, L., Lim, L. and Manser, E. ( 2001 ). The mechanism of PAK...
Journal Articles
J Cell Sci (2008) 121 (7): 933–938.
Published: 1 April 2008
...-myc vector. Rac1 Q61L was subcloned into pRK5-myc and pRK5-FLAG. PAK auto-inhibitory domain (PAK AID ) and ROCKα kinase-dead in pRK5-myc were a gift from Alan Hall (Memorial Sloane-Kettering Cancer Center, New York, NY). PAK1 K299R and PAK1 H83L,H86L,K299R were provided by Jonathan Chernoff (Fox...
Includes: Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3583–3592.
Published: 1 September 2006
... (e-mail: horwitz@virginia.edu ) 5 6 2006 © The Company of Biologists Limited 2006 2006 Cell migration Polarity Rho GTPases Phosphoinositide-3 kinase PAK Actomyosin Directed cell migration, an essential process in the development of multicellular organisms, relies...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2001) 114 (23): 4239–4251.
Published: 1 December 2001
...Cheng-Gee Koh; Ed Manser; Zhou-Shen Zhao; Chee-Peng Ng; Louis Lim PIX is a Rho-family guanine nucleotide exchange factor that binds PAK. We previously described two isoforms of PIX that differ in their N termini. Here, we report the identification of a new splice variant of βPIX, designated β2PIX...
Journal Articles
J Cell Sci (2001) 114 (11): 1973–1980.
Published: 1 June 2001
... for correspondence (e-mail: davie@hms.harvard.edu ) © The Company of Biologists Limited 2001 2001 GTPase Rho family Actin Rac Pak Dock Kalirin The development of the embryonic nervous system requires that nascent axons extend across a complex extracellular terrain in order to reach...