...Aline Bozec; Latifa Bakiri; Maria Jimenez; Evan D. Rosen; Philip Catalá-Lehnen; Thorsten Schinke; Georg Schett; Michael Amling; Erwin F. Wagner Summary Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone...

...; Manas Ray; S. Liu; James F. Martin; Yuji Mishina; Stephen E. Harris Summary We generated a new Bmp2 conditional-knockout allele without a neo cassette that removes the Bmp2 gene from osteoblasts (Bmp2-cKO ob ) using the 3.6Col1a1-Cre transgenic model. Bones of Bmp2-cKO ob mice are thinner...

... showed marginal differences, the Cx3cr1 -deficient bones showed an elevated expression of Osterix/SP7 , which encodes an essential transcriptional factor for osteoblasts, whereas the gene Osteocalcin /Bglap , which encodes a late marker, was downregulated. The levels of transcripts for various...

...Carlos Zaragoza; Esther López-Rivera; Concepción García-Rama; Marta Saura; Antonio Martínez-Ruíz; Tania R. Lizarbe; Fernando Martín-de-Lara; Santiago Lamas During bone development, osteoblast differentiation requires remodeling of the extracellular matrix. Although underlying mechanisms have...

... of osteoblasts, and depends on fibronectin for its assembly. To gain further insights into the mechanisms of assembly of LTBP1 and its spatial and temporal interactions with fibronectin, we have performed dual fluorescence time-lapse imaging of these two proteins in living osteoblasts using fluorescent probes...

...Sami Curtze; Micah Dembo; Miguel Miron; David B. Jones Primary bovine osteoblasts and human osteosarcoma cells exposed to direct-current electric fields undergo processes of retraction and elongation ultimately resulting in the realignment of the long cellular axis perpendicular to the electric...

... and shared significantly reduced longitudinal bone growth. Mutant long bones were characterised by reduced numbers of growth plate chondrocytes and a severe osteoporosis. Decreased JunB levels in epiphysal growth plate chondrocytes and bone lining osteoblasts correlated with deregulated expression of Cyclin...

...Fina Liu; Luc Malaval; Jane E. Aubin Mesenchymal stem cells give rise to osteoprogenitors that proliferate and differentiate into identifiable preosteoblasts, osteoblasts, bone lining cells and osteocytes. To identify and establish a molecular profile for the more primitive and uncharacterized...

... of the osteoblast-specific osteocalcin gene in osseous cells. Taken together, these findings identify a critical component of the mechanisms mediating Runx2 targeting to subnuclear foci and provide functional linkage between subnuclear organization of Runx2 and bone-specific transcriptional control. ‡Author...

... of osteoblast ontogeny. More generally it emphasizes the potential of the pK4-immortalized cell lines for the study of lineage specification. * Author for correspondence 16 04 1993 13 07 1993 © 1993 by Company of Biologists 1993 immortalization SV40 oncogenes osteoblasts...

..., are thought to influence osseointeg-ration. Despite the known importance of this interface, little is known about the factors that promote its formation. In this study, chick embryonic calvarial osteoblasts were cultured in vitro on smooth, rough-textured and porous-coated titanium surfaces and examined...