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Keywords: Oscillations
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Journal Articles

Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay

Joseph A. Brzostowski, Satoshi Sawai, Orr Rozov, Xin-hua Liao, Daisuke Imoto, Carole A. Parent, Alan R. Kimmel
Journal: Journal of Cell Science
J Cell Sci (2013) 126 (20): 4614–4626.
DOI: https://doi.org/10.1242/jcs.122952
Published: 15 October 2013
... Dictyostelium , secreted cAMP serves as a chemoattractant, with extracellular cAMP propagated as oscillating waves to ensure directional migratory signals. cAMP oscillations derive from transient excitatory responses of adenylyl cyclase, which then rapidly adapts. We have studied chemotactic signaling...
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Includes: Supplementary data
Journal Articles

Distinct plasma-membrane PtdIns(4) P and PtdIns(4,5) P 2 dynamics in secretagogue-stimulated β-cells

Anne Wuttke, Jenny Sågetorp, Anders Tengholm
Journal: Journal of Cell Science
J Cell Sci (2010) 123 (9): 1492–1502.
DOI: https://doi.org/10.1242/jcs.060525
Published: 1 May 2010
... by phospholipase C (PLC)-activating receptor agonists or stimulatory glucose concentrations was paralleled by increased PtdIns(4) P levels. In addition, glucose-stimulated cells regularly showed anti-synchronous oscillations of the two lipids. Whereas glucose-induced PtdIns(4) P elevation required voltage-gated Ca...
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Includes: Supplementary data