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Keywords: ORAI1
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Immunofluorescence image of a primary adult neural stem cell-derived neuron...
Published: 28 February 2024
Immunofluorescence image of a primary adult neural stem cell-derived neuron. Even though the neurogenic transcription factor Meis2 is already expressed within the V-SVZ stem cell population, it is rather instable and barely detectable at the protein level. Upon neuronal differentiation, MEIS2 pro... More about this image found in Immunofluorescence image of a primary adult neural stem cell-derived neuron...
Journal Articles
Journal Articles
Journal Articles
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Organization of the primary cilium and key steps in its biogenesis.  (A) Th...
Published: 28 February 2024
Fig. 1. Organization of the primary cilium and key steps in its biogenesis. (A) The primary cilium, pericentriolar matrix and centriolar satellites. The primary cilium is a microtubule-based projection of the plasma membrane comprising a microtubule-based axoneme that extends from the older of t... More about this image found in Organization of the primary cilium and key steps in its biogenesis. (A) Th...
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CP110 removal by direct ubiquitylation of the CP110–CEP97 capping complex. ...
Published: 28 February 2024
Fig. 2. CP110 removal by direct ubiquitylation of the CP110–CEP97 capping complex. (A) Mechanism of CP110 removal by CEP78 recruitment of EDD1–DYRK2–DDB1 VPRBP (DYRK2) to the mother centriole. CEP78 is recruited to the centrosome by CEP350, where it interacts with the E3 ligase complex DYRK2. D... More about this image found in CP110 removal by direct ubiquitylation of the CP110–CEP97 capping complex. ...
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CP110 removal involving centriolar satellites and microtubule-binding prote...
Published: 28 February 2024
Fig. 3. CP110 removal involving centriolar satellites and microtubule-binding protein KIF24. (A) Mechanism of CP110 removal by HERC2 ubiquitylation of CP110. PCM1-marked centriolar satellites, which have been described as ‘protein reservoirs for the centrosome’ ( Bärenz et al., 2011 ) can traffi... More about this image found in CP110 removal involving centriolar satellites and microtubule-binding prote...
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CP110 removal via destabilization and autophagy of the CP110–CEP97 capping ...
Published: 28 February 2024
Fig. 4. CP110 removal via destabilization and autophagy of the CP110–CEP97 capping complex. (A) Mechanism of CP110 removal by competitive interaction with ENKD1. ENKD1 interacts with CP110, thus competing with and preventing binding of CP110 to CEP97. The loss of a stable CP110–CEP97 complex at ... More about this image found in CP110 removal via destabilization and autophagy of the CP110–CEP97 capping ...
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Strategy to compare two types of TORC1 in  S. cerevisiae .  (A) Orthologue ...
Published: 28 February 2024
Fig. 1. Strategy to compare two types of TORC1 in S. cerevisiae . (A) Orthologue proteins that constitute TORC1 and TORC2 in several species. Only S. cerevisiae has two types of TORC1, namely Tor1-TORC1 and Tor2-TORC1. (B) Tor2-TORC1 in S. cerevisiae is deleted by engineering Tor2 to mainta... More about this image found in Strategy to compare two types of TORC1 in S. cerevisiae . (A) Orthologue ...
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Strategy to create and compare two model structures to find a mutation targ...
Published: 28 February 2024
Fig. 2. Strategy to create and compare two model structures to find a mutation target region in Tor2. (A) Model building protocol and model structures of Tor2-TORC1 (top) and TORC2 (bottom) (Lst8 is omitted). Homology models of each constituent protein were superimposed on the constituent protei... More about this image found in Strategy to create and compare two model structures to find a mutation targ...
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Strategy to design Tor2 mutants to form TORC2 but not TORC1, and a cell-bas...
Published: 28 February 2024
Fig. 3. Strategy to design Tor2 mutants to form TORC2 but not TORC1, and a cell-based assay for the redesigned Tor complexes with TORC2 function but no TORC1 function. (A) Illustrative case of the A775 residue of Tor2 in the redesign strategy. A775 in the design target region was mutated to glut... More about this image found in Strategy to design Tor2 mutants to form TORC2 but not TORC1, and a cell-bas...
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The Tor2(K12) mutant almost loses TORC1-assembling ability and retains TORC...
Published: 28 February 2024
Fig. 4. The Tor2(K12) mutant almost loses TORC1-assembling ability and retains TORC2-assembling ability. (A) Formation of Tor1-TORC1 and Tor2-TORC1. Flag-tagged Kog1 ( Flag Kog1) was immunoprecipitated from cell lysates of wild-type, tor2 (K12) and tor1 Δ strains expressing either HA-tagged To... More about this image found in The Tor2(K12) mutant almost loses TORC1-assembling ability and retains TORC...
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Cell phenotypes induced by Tor2(K12).  (A) Cell growth in the presence of r...
Published: 28 February 2024
Fig. 5. Cell phenotypes induced by Tor2(K12). (A) Cell growth in the presence of rapamycin (Rapa) or caffeine treatments. Growth of the tor2 (K12) strain (K12) has higher sensitivity to 2.5 ng/ml rapamycin, a selective inhibitor of TORC1, and 3 mM caffeine, an inhibitor of TORC1, as compared to... More about this image found in Cell phenotypes induced by Tor2(K12). (A) Cell growth in the presence of r...
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Calpain-2 protease activity is high in primary aNS and downregulated upon d...
Published: 28 February 2024
Fig. 1. Calpain-2 protease activity is high in primary aNS and downregulated upon differentiation. (A) Schematic representation of the neurosphere assay. (B) Normalized transcript levels of calpain proteases in aNS and neurons. n =3. nd, no transcript detected. P -values are indicated [one-way... More about this image found in Calpain-2 protease activity is high in primary aNS and downregulated upon d...
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Inhibition of calpain-2 enhances whereas its activation reduces  in vitro  ...
Published: 28 February 2024
Fig. 2. Inhibition of calpain-2 enhances whereas its activation reduces in vitro neuronal differentiation of aNS. (A) Schema of CAPN2 and CAPN4 domains. PC, protease domain; PEF, penta-EF-hand domain; FLAG, FLAG tag. Phosphosite S50 is indicated, the constitutively active mutation is S50D. (B)... More about this image found in Inhibition of calpain-2 enhances whereas its activation reduces in vitro ...
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MEIS2 in aNS and differentiating neurons.  (A) Schematic overview of the an...
Published: 28 February 2024
Fig. 3. MEIS2 in aNS and differentiating neurons. (A) Schematic overview of the antibody staining applied in this figure. Two antibodies, directed against the N- and C-terminus of MEIS2 have been used. Staining intensities of the N-terminal antibody and C-terminal antibody within single cells we... More about this image found in MEIS2 in aNS and differentiating neurons. (A) Schematic overview of the an...